Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review
KW Taylor, RF Novak, HA Anderson… - Environmental …, 2013 - ehp.niehs.nih.gov
Background: Diabetes is a major threat to public health in the United States and worldwide.
Understanding the role of environmental chemicals in the development or progression of …
Understanding the role of environmental chemicals in the development or progression of …
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression
SK Kim, RF Novak - Pharmacology & therapeutics, 2007 - Elsevier
Endogenous factors, including hormones, growth factors and cytokines, play an important
role in the regulation of hepatic drug metabolizing enzyme expression in both physiological …
role in the regulation of hepatic drug metabolizing enzyme expression in both physiological …
The alcohol-inducible form of cytochrome P450 (CYP2E1): role in toxicology and regulation of expression
RF Novak, KJ Woodcroft - Archives of pharmacal research, 2000 - Springer
Cytochrome P450 (CYP) 2E1 catalyzes the metabolism of a wide variety of therapeutic agents,
procarcinogens, and low molecular weight solvents. CYP2E1-catalyzed metabolism may …
procarcinogens, and low molecular weight solvents. CYP2E1-catalyzed metabolism may …
Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression
KJ Woodcroft, MS Hafner, RF Novak - Hepatology, 2002 - Elsevier
… Zangar RC, Novak RF. Effects of fatty acids and ketone bodies on cytochromes P450 2B,
4A… Woodcroft KJ, Novak RF. The role of phosphatidylinositol 3-kinase, Src kinase, and protein …
4A… Woodcroft KJ, Novak RF. The role of phosphatidylinositol 3-kinase, Src kinase, and protein …
miRNAs: effectors of environmental influences on gene expression and disease
A Hudder, RF Novak - Toxicological sciences, 2008 - academic.oup.com
… identified miRNAs that are responsible for the downregulation of CYP2E1 expression in
primary rat hepatocytes and experimentally confirmed their function (Overton, Hudder and Novak…
primary rat hepatocytes and experimentally confirmed their function (Overton, Hudder and Novak…
ER fluid requirements for automotive devices
DL Hartsock, RF Novak, GJ Chaundy - Journal of rheology, 1991 - pubs.aip.org
The requirements necessary for electrorheological fluids to be used in automotive devices
are discussed along with the necessary fluid design data. As part of this discussion the …
are discussed along with the necessary fluid design data. As part of this discussion the …
Insulin effects on CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes
KJ Woodcroft, RF Novak - Chemico-biological interactions, 1997 - Elsevier
… [34] RC Zangar, RF Novak, Effects of fatty acids and ketone bodies on cytochromes P450
2B, 4A, and 2El expression in primary cultured rat hepatocytes, Arch. Biochem. Biophys. …
2B, 4A, and 2El expression in primary cultured rat hepatocytes, Arch. Biochem. Biophys. …
Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative …
…, SK Kim, KJ Woodcroft, RF Novak - Journal of Pharmacology …, 2004 - ASPET
… , and RF Novak, unpublished data). Because CYP2E1 metabolism can result in formation
of reactive metabolites and CYP2E1 has been implicated in the generation of tissue-damaging …
of reactive metabolites and CYP2E1 has been implicated in the generation of tissue-damaging …
Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes
RC Zangar, RF Novak - Archives of biochemistry and biophysics, 1997 - Elsevier
CYP2B, CYP4A, and CYP2E1 mRNA levels are elevated in response to pathophysiological
conditions, such as diabetes, high-fat diet, and fasting, in which lipids and ketone bodies are …
conditions, such as diabetes, high-fat diet, and fasting, in which lipids and ketone bodies are …
Insulin signaling regulates γ-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes
…, KJ Woodcroft, SS Khodadadeh, RF Novak - Journal of Pharmacology …, 2004 - ASPET
Decreased glutathione (GSH) levels and γ-glutamylcysteine ligase (GCL) activity have been
observed in diabetic patients, and insulin reportedly increases GSH synthesis via increased …
observed in diabetic patients, and insulin reportedly increases GSH synthesis via increased …