User profiles for R. C. Pierce

R. Christopher Pierce

Rutgers University
Verified email at rutgers.edu
Cited by 14238

A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants

RC Pierce, PW Kalivas - Brain research reviews, 1997 - Elsevier
Repeated exposure to psychostimulants such as cocaine and amphetamine produces
behavioral sensitization, which is characterized by an augmented locomotor response to a …

The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?

RC Pierce, V Kumaresan - Neuroscience & biobehavioral reviews, 2006 - Elsevier
In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system. The …

A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission

GV Rebec, RC Pierce - Progress in neurobiology, 1994 - Elsevier
5.1. Interaction with the dopaminergic system 5.1. 1. Dopamine receptor binding experiments
5.1. 2. Behavioral and biochemical evidence 5.2. Interaction with the glutamatergic system …

Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization

RC Pierce, K Bell, P Duffy, PW Kalivas - Journal of Neuroscience, 1996 - Soc Neuroscience
Rats were pretreated with daily cocaine or saline injections for 1 week. The rats treated with
daily cocaine were separated into two groups: a sensitized group of animals demonstrating …

Epigenetic inheritance of a cocaine-resistance phenotype

…, SL White, HD Schmidt, G Sadri-Vakili, RC Pierce - Nature …, 2013 - nature.com
We delineated a heritable phenotype resulting from the self-administration of cocaine in rats.
We observed delayed acquisition and reduced maintenance of cocaine self-administration …

Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the …

…, RD Spealman, JK Rowlett, RC Pierce - Journal of …, 2002 - Soc Neuroscience
One of the major determinants of reinstatement to cocaine use among human addicts is acute
reexposure to the drug, which often precipitates cocaine craving and relapse. We used an …

[PDF][PDF] Sliced human cortical organoids for modeling distinct cortical layer formation

…, SE Swinford-Jackson, Z Wen, X Gu, RC Pierce… - Cell stem cell, 2020 - cell.com
Human brain organoids provide unique platforms for modeling development and diseases
by recapitulating the architecture of the embryonic brain. However, current organoid methods …

CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking

…, CE Bass, EF Terwilliger, JHJ Cha, RC Pierce - Nature …, 2008 - nature.com
Increases in dopamine and glutamate transmission in the nucleus accumbens independently
promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have …

Cocaine‐induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction

HD Schmidt, RC Pierce - Annals of the New York Academy of …, 2010 - Wiley Online Library
A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …

Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated …

RC Pierce, PW Kalivas - Journal of Pharmacology and Experimental …, 1995 - ASPET
Alterations in dopamine transmission in the nucleus accumbens, which is composed of two
anatomically distinct compartments termed the shell and core, contribute to the expression of …