[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
…, C Borner, J Boettger, A Braeuning, RA Budinsky… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
[HTML][HTML] Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes
…, JC Rowlands, RA Budinsky, RA Becker - Regulatory Toxicology …, 2015 - Elsevier
An adverse outcome pathway (AOP) describes the causal linkage between initial molecular
events and an adverse outcome at individual or population levels. Whilst there has been …
events and an adverse outcome at individual or population levels. Whilst there has been …
Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice
…, V Soldatow, EL LeCluyse, RA Budinsky… - Toxicology and applied …, 2013 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor which plays a
role in the development of multiple tissues and is activated by a large number of ligands, …
role in the development of multiple tissues and is activated by a large number of ligands, …
Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study
RA Budinsky, D Schrenk, T Simon… - Critical reviews in …, 2014 - Taylor & Francis
Dioxins and dioxin-like compounds are tumor promoters that cause liver cancer in rats and
mice. The aryl hydrocarbon receptor (AHR) has been implicated as a key component in this …
mice. The aryl hydrocarbon receptor (AHR) has been implicated as a key component in this …
Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline
LJC Bolchoz, RA Budinsky, DC McMillan… - Journal of Pharmacology …, 2001 - ASPET
Primaquine is an important antimalarial agent because of its activity against exoerythrocytic
forms of Plasmodium spp. However, methemoglobinemia and hemolytic anemia are dose-…
forms of Plasmodium spp. However, methemoglobinemia and hemolytic anemia are dose-…
Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice
…, JR Harkema, JC Rowlands, RA Budinsky… - Toxicological …, 2010 - academic.oup.com
The toxic equivalency factor (TEF) approach recommended by the World Health Organization
is used to quantify dioxin-like exposure concentrations for mixtures of polychlorinated …
is used to quantify dioxin-like exposure concentrations for mixtures of polychlorinated …
Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
MB Black, RA Budinsky, A Dombkowski… - Toxicological …, 2012 - academic.oup.com
A toxicogenomics approach was used to qualitatively and quantitatively compare the gene
expression changes in human and rat primary hepatocytes exposed to 2,3,7,8-…
expression changes in human and rat primary hepatocytes exposed to 2,3,7,8-…
[HTML][HTML] The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor
…, TW Simon, JC Rowlands, RA Budinsky - Regulatory Toxicology …, 2015 - Elsevier
An Adverse Outcome Pathway (AOP) represents the existing knowledge of a biological pathway
leading from initial molecular interactions of a toxicant and progressing through a series …
leading from initial molecular interactions of a toxicant and progressing through a series …
A pilot study of oral bioavailability of dioxins and furans from contaminated soils: Impact of differential hepatic enzyme activity and species differences
RA Budinsky, JC Rowlands, S Casteel, G Fent… - Chemosphere, 2008 - Elsevier
An in vivo pilot study of the oral bioavailability of polychlorinated dibenzo-p-dioxins (PCDDs)
and polychlorinated dibenzofurans (PCDFs) in two soils with distinct congener profiles (one …
and polychlorinated dibenzofurans (PCDFs) in two soils with distinct congener profiles (one …
Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
…, M Lawson, G Martin, RA Budinsky… - Journal of Applied …, 2016 - Wiley Online Library
Sustained activation of the aryl hydrocarbon receptor (AHR) is believed to be the initial key
event in AHR receptor‐mediated tumorigenesis in the rat liver. The role of AHR in mediating …
event in AHR receptor‐mediated tumorigenesis in the rat liver. The role of AHR in mediating …