Molecular techniques allowing in vivo modulation of gene expression have provided unique
opportunities and challenges for behavioural studies aimed at understanding the function of …

… Georgsen, P. Morel, C. Naegelen, L. … P. Cazenave, J. Dreier, T. … de Korte, PF van der
Meer, JL Kerkhoffs, L. Blanco, J. Kjeldsen‐Kragh, A.‐…

Simple Summary The value of animal research has been increasingly debated, owing to
high failure rates in drug development. A potential contributor to this situation is the lack of …

As the healthcare community has begun to rely increasingly upon digital technologies for
acquisition, storage, and transmission of pictorial data, image compression has become an …

The immunogenicity of biopharmaceuticals used in clinical practice remains an unsolved
challenge in drug development. Non-human primates (NHPs) are often the only relevant …

The value of animal studies to assess drug safety is unclear because many such studies are
biased and have methodological shortcomings. We studied whether post-marketing serious …

Introduction Poor translation of efficacy data derived from animal models can lead to clinical
trials unlikely to benefit patients–or even put them at risk–and is a potential contributor to …

Clinical trial failures (>99%) in Alzheimer's disease are in stark contrast to positive efficacy
data in animals. We evaluated the correlation between animal and clinical efficacy outcomes (…

Nonclinical studies in animals are conducted to demonstrate proof-of-concept, mechanism of
action and safety of new drugs. For a large part, in particular safety assessment, studies are …

Land property rights take many forms, of which individual and joint ownership are only two.
Individual ownership means that one person owns each cadastral plot. Joint ownership …