Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile
duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western …

… hOCT1 (*P < 0.001 and **P < 0.01 versus control), and all NSAIDs except acetaminophen
significantly inhibited TEA uptake mediated by hOCT2 (*P < 0.001, **P < 0.01 and ***P < 0.05 …

Piperine is acutely toxic to mice, rats and hamsters. The LD 50 values for a single iV, ip, sc,
ig and im administration of piperine to adult male mice were 15.1, 43, 200, 330 and 400 mg/…

… high estrogenic activity are the presence of an olefinic function conjugated with the aromatic
ring at the 7-position, a keto group at the 3-position, and a phenolic hydroxyl group at the p-…

… Statistical significance was determined using an unpaired t-test for two means where P <
0.05 was taken as the limit denoting … P < 0.01 compared with the MB control of each group. …

A rhodamine derivative ZP1, appended with two 1,2,3-triazole moieties via a diaminopropyl
linker, is a chromogenic and fluorogenic sensor for Zn 2+ . In the presence of Zn 2+ , a …

Cholangiocarcinoma (CCA), a common primary malignant tumor of bile duct epithelia, is highly
prevalent in Asian countries and unresponsive to chemotherapeutic drugs. Thus, a newly …

Estrogen promotes growth in many tissues by activating Wnt/β-catenin signaling. Recently,
ASPP 049, a diarylheptanoid isolated from Curcuma comosa Roxb., has been identified as a …

… P < 0.05 was regarded as statistically significant. EC 50 value was calculated from the
non-linear regression curve-fitting … P < 0.01 between control and treatment groups by using t-test. …

… A P value of less than 0.05 was considered statistically significant. IBM SPSS statistics for
Windows, version 23.0 (IBM Corp., Armonk, New York, USA) was used for statistical analyses. …