Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

JM Stadel, P Nambi, RG Shorr… - Proceedings of the …, 1983 - National Acad Sciences
Preincubation of turkey erythrocytes with catecholamines desensitizes the beta-adrenergic
receptor-adenylate cyclase complex in the plasma membranes of these cells. Photoaffinity …

[HTML][HTML] Molecular characterization and regulation of the human endothelin receptors.

…, DJ Bergsma, CS Kumar, P Nambi - Journal of Biological …, 1993 - Elsevier
Endothelin receptors (ETRs) are distributed throughout a variety of tissues. Two human
cDNAs were identified which encode distinct ETR proteins. One cDNA encoded a 427-amino …

Liver X receptor (LXR)-β regulation in LXRα-deficient mice: implications for therapeutic targeting

…, GU Schuster, JĊ Gustafsson, MD Basso, P Nambi - Molecular …, 2006 - ASPET
The nuclear receptors liver X receptor (LXR) LXRα and LXRβ are differentially expressed
ligand-activated transcription factors that induce genes controlling cholesterol homeostasis …

[HTML][HTML] Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

…, AR Halpern, L Chen, CP Miller, P Nambi - Journal of lipid …, 2004 - ASBMB
Liver X receptors (LXRs) play key roles in the regulation of cholesterol homeostasis by limiting
cholesterol accumulation in macrophages within arterial wall lesion sites by a mechanism …

[HTML][HTML] LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse [S]

…, WM Mounts, ER LaVallie, J Wrobel, P Nambi… - Journal of lipid …, 2009 - ASBMB
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation
of gene expression involved in several cellular functions but most notably cholesterol …

Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.

DR Sibley, JR Peters, P Nambi, MG Caron… - Journal of Biological …, 1984 - ASBMB
Preincubation of turkey erythrocytes with beta-adrenergic agonists leads to an attenuation of
the responsiveness of adenylate cyclase to subsequent hormonal stimulation. Recently, our …

Reversal of postischemic acute renal failure with a selective endothelinA receptor antagonist in the rat.

…, T Fletcher, R DeWolf, P Nambi - The Journal of …, 1994 - Am Soc Clin Investig
Studies were designed to examine the effect of a selective endothelinA (ETA) receptor
antagonist, BQ123, on severe postischemic acute renal failure (ARF) in Sprague-Dawley rats. …

G protein-coupled receptors in drug discovery

P Nambi, N Aiyar - Assay and drug development technologies, 2003 - liebertpub.com
… Ponnal Nambi would like to thank Professor RJ Lefkowitz for giving her the opportunity to do
her postdoctoral research in his laboratory. It has proven to be a most invaluable experience…

Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis

…, M Basso, V Clerin, SJ Gardell, P Nambi… - Journal of medicinal …, 2008 - ACS Publications
A series of substituted 2-benzyl-3-aryl-7-trifluoromethylindazoles were prepared as LXR
modulators. These compounds were partial agonists in transactivation assays when compared …

[PDF][PDF] Histoplasmosis in India: truly uncommon or uncommonly recognised

R Gopalakrishnan, PS Nambi… - J Assoc Physicians …, 2012 - researchgate.net
Objectives: to study the clinical profile of patients with proven histoplasmosis who had
presented to a tertiary care referral centre. Methods: We retrospectively analysed the medical …