The discovery of a pyrrolopyrimidine class of LIM-kinase 2 (LIMK2) inhibitors is reported.
These LIMK2 inhibitors show good potency in enzymatic and cellular assays and good …

Purpose: Diabetic macular edema (DME), an accumulation of fluid in the subretinal space,
is a significant cause of vision loss. The impact of diabetes on the breakdown of the inner …

purpose. Studies have shown that the activation of adenosine A 1 receptors lower intraocular
pressure primarily by increasing total outflow facility. The purpose of this study was to …

Adenylyl cyclases present a potential focal point for signal integration in vascular smooth
muscle cells (VSMC) influencing contractile state and cellular responses to vessel wall injury. …

Purpose.: The current studies investigate if the histone deacetylase (HDAC) inhibitor,
valproic acid (VPA), can limit retinal ganglion cell (RGC) degeneration in an ocular-hypertensive …

Increased histone deacetylase (HDAC) activity and the resulting dysregulation of protein
acetylation is an integral event in retinal degenerations associated with ischemia and ocular …

Introduction: The topical application of prostaglandin F 2α (FP)-receptor agonists has been
shown to significantly lower intraocular pressure (IOP) in humans and is now considered the …

The aim of this study was to investigate the effects of bradykinin on conventional outflow
facility in relation to kinin effects on matrix metalloproteinase (MMP) secretion. Conventional …

The purpose of this study was to determine whether functional purinergic P2 receptors are
present in trabecular meshwork cells. The human trabecular cell line HTM-3 and cultured …

Kinins and prostaglandins activate signalling pathways in cells of the trabecular meshwork
and have opposing effects on outflow resistance to aqueous humor. Consequently, …