Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover
PJ Blackshear - Biochemical Society Transactions, 2002 - portlandpress.com
The tristetraprolin (TTP) family of CCCH tandem zinc-finger proteins is composed of three
known members in mammals, with a fourth member recently identified in frogs and fish. …
known members in mammals, with a fourth member recently identified in frogs and fish. …
Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action
SA Brooks, PJ Blackshear - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
… PJ Blackshear, unpublished data); in this predicted protein, the TZF domain represents the
extreme C-terminal 65 amino acids. Although target sequences have not been analyzed in …
extreme C-terminal 65 amino acids. Although target sequences have not been analyzed in …
RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins
M Fu, PJ Blackshear - Nature Reviews Immunology, 2017 - nature.com
… Carballo, E., Lai, WS & Blackshear, PJ Feedback inhibition of macrophage tumor necrosis
factor-α production by tristetraprolin. Science 281, 1001–1005 (1998). This report is the first to …
factor-α production by tristetraprolin. Science 281, 1001–1005 (1998). This report is the first to …
Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin
E Carballo, WS Lai, PJ Blackshear - Science, 1998 - science.org
Tumor necrosis factor–α (TNF-α) is a major mediator of both acute and chronic inflammatory
responses in many diseases. Tristetraprolin (TTP), the prototype of a class of Cys-Cys-Cys-…
responses in many diseases. Tristetraprolin (TTP), the prototype of a class of Cys-Cys-Cys-…
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
…, RS Phillips, PJ Blackshear - … and cellular biology, 1999 - Am Soc Microbiol
Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH zinc finger proteins,
develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α). …
develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α). …
[PDF][PDF] A pathogenetic role for TNFα in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
…, HE Broxmeyer, BF Haynes, PJ Blackshear - Immunity, 1996 - cell.com
Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two
unusual CCCH zinc fingers and is encoded by the immediate–early response gene, Zfp-36. …
unusual CCCH zinc fingers and is encoded by the immediate–early response gene, Zfp-36. …
Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
…, WS Lai, PJ Blackshear - Blood, The Journal of the …, 2000 - ashpublications.org
Deficiency of tristetraprolin (TTP), the prototype of the CCCH zinc finger proteins, results in a
complex inflammatory syndrome in mice. Most aspects of the syndrome are secondary to …
complex inflammatory syndrome in mice. Most aspects of the syndrome are secondary to …
[PDF][PDF] Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA
…, K Barnouin, AP Snijders, WS Lai, PJ Blackshear… - Immunity, 2017 - cell.com
The immunosuppressive protein PD-L1 is upregulated in many cancers and contributes to
evasion of the host immune system. The relative importance of the tumor microenvironment …
evasion of the host immune system. The relative importance of the tumor microenvironment …
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression …
…, D Radzioch, AR Clark, PJ Blackshear… - … and cellular biology, 2006 - Taylor & Francis
The mitogen-activated protein kinase (MAPK) p38/MAPK-activated protein kinase 2 (MK2)
signaling pathway plays an important role in the posttranscriptional regulation of tumor …
signaling pathway plays an important role in the posttranscriptional regulation of tumor …
[HTML][HTML] Interactions of CCCH zinc finger proteins with mRNA: binding of tristetraprolin-related zinc finger proteins to AU-rich elements and destabilization of mRNA
…, JM Thorn, EA Kennington, PJ Blackshear - Journal of Biological …, 2000 - ASBMB
Macrophages derived from tristetraprolin (TTP)-deficient mice exhibited increased tumor
necrosis factor α (TNFα) release as a consequence of increased stability of TNFα mRNA. TTP …
necrosis factor α (TNFα) release as a consequence of increased stability of TNFα mRNA. TTP …