… of PLD by pharmacologic stimulants and receptor ligands and further enhanced the potentiating
effects of cholera toxin (PF Fraundorfer, J. Rivera, and MA Beaven, unpublished data). …

The role of phospholipase (PL) D in secretion was examined in RBL-2H3 mast cells which
contain both PLD1 and 2. The effects of pharmacologic stimulants and inhibitors of Ca 2+ /…

Functions attributed to phospholipase (PL) D include the regulation of intracellular trafficking
of Golgi‐derived vesicles and secretion of granules from mast cells. We have reported that …

The adenosine analog, N-ethylcarboxamidoadenosine (NECA), causes transient activation
of phospholipase C and an enhancement of antigen-induced secretion in a rat mast cell (RBL…

The 5, 8-difluoro (4), 5-iodo (5), 8-iodo (6), and 5-trifluoromethyl (7) derivatives of trimetoquinol
(TMQ, 1) have been synthesized and evaluated for their ability to stimulate 8i (guinea pig …

Release of secretory granules by rat RBL-2H3 mast cells is mediated primarily through
activation of protein kinase C (PKC) and elevation of cytosolic free calcium ([Ca ++ ] I ). Here, we …

ABSTRACT ABBREVIATiONS: TMQ, tnmetoquinol; THI, tetrahydroisoquinoline; AR,
adrenergic receptor; CHO, Chinese hamster ovary; CAMP, cyclic AMP;

… Fraundorfer thanks the American Foundation for Pharmaceutical Education for support as a
… Fraundorfer, P. Functional and biochemical characterization of trimetoquino1 (TMQ) analog …

The β-adrenoceptor activities of trimetoquinol (TMQ) isomers and selected derivatives were
evaluated on human β-adrenoceptor subtypes expressed in Chinese hamster ovary cells. In …

The site of interaction for the 1-(3′,4′,5′-trimethoxybenzyl) group of trimetoquinol (TMQ)
with β-adrenoceptors (β-ARs) is important for the rational design of highly potent and β 3 -AR…