The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic,
whereas the microenvironment of tissues affected by chronic inflammatory disease is pro-…

Misoprostol, a synthetic prostaglandin E1 analogue, is commonly used for medical abortion,
cervical priming, the management of miscarriage, induction of labor and the management of …

Recent progress in cancer immunotherapy emphasizes the importance of understanding
immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to …

Electrons in correlated insulators are prevented from conducting by Coulomb repulsion
between them. When an insulator-to-metal transition is induced in a correlated insulator by …

Conventional photodynamic therapy (PDT) is limited by the penetration depth of visible light
needed for its activation. Here we used mesoporous-silica–coated upconversion fluorescent …

Activated T cells engage aerobic glycolysis and anabolic metabolism for growth, proliferation,
and effector functions. We propose that a glucose-poor tumor microenvironment limits …

Evidence from mouse chronic viral infection models suggests that CD8 + T cell subsets
characterized by distinct expression levels of the receptor PD-1 diverge in their state of …

BACKGROUND: The pharmacokinetic parameters of four different routes of administration
of a single dose of 400 μg of misoprostol were studied. METHODS: A total of 40 women …

Superconductivity has been observed in PrOs 4 Sb 12 at TC= 1.85 K and appears to involve
heavy fermion quasiparticles with an effective mass m*∼ 50 me as inferred from the jump in …

To the Editors: On May 2, 2007, the US Food and Drug Administration expanded black box
warnings of all antidepressant medications to include information about an increased risk of …