Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells

…, M Kohyama, LA Benoit, PA Klekotka… - Journal of Experimental …, 2010 - rupress.org
Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid tissues,
the transcription factors controlling their development and their relationship to other DC …

A prospective phase III, randomized, double‐blind, placebo‐controlled study of brodalumab in patients with moderate‐to‐severe plaque psoriasis

…, CE Milmont, J Li, PA Klekotka… - British Journal of …, 2016 - academic.oup.com
Background The interleukin‐17 cytokine family plays a central role in psoriasis
pathogenesis. Objectives To evaluate the efficacy and safety of brodalumab, a human anti‐interleukin‐17 …

[HTML][HTML] α2 integrin subunit cytoplasmic domain-dependent cellular migration requires p38 MAPK

PA Klekotka, SA Santoro, MM Zutter - Journal of Biological Chemistry, 2001 - ASBMB
The α 2 integrin subunit cytoplasmic domain uniquely supported epidermal growth factor (EGF)-stimulated
migration on type I collagen. p38 MAP kinase- and phosphatidylinositol 3-…

[HTML][HTML] Specific residues within the α2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathways

PA Klekotka, SA Santoro, H Wang, MM Zutter - Journal of Biological …, 2001 - ASBMB
The α 2 integrin subunit cytoplasmic domain is necessary for epidermal growth factor (EGF)-stimulated
chemotactic migration and insulin-dependent entry into S-phase of mammary …

[HTML][HTML] Contrasting roles of the IL-1 and IL-18 receptors in MyD88-dependent contact hypersensitivity

PA Klekotka, L Yang, WM Yokoyama - Journal of investigative dermatology, 2010 - Elsevier
Contact hypersensitivity (CHS) requires activation of the innate immune system, and results
in an adaptive immune response. Many cells of the innate immune system use Toll-like …

Seasonal variation of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with trimethoprim-sulfamethoxazole

KA Wanat, MJ Anadkat, PA Klekotka - Journal of the American Academy of …, 2009 - Elsevier
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)
are rare and severe cutaneous adverse reactions to medications and infections. OBJECTIVE: …

Differences in psoriasis signs and symptom severity between patients with clear and almost clear skin in clinical practice

SR Feldman, DM Bushnell, PA Klekotka… - Journal of …, 2016 - Taylor & Francis
Introduction: In psoriasis clinical trials, treatment success is often defined as achieving a
static Physician Global Assessment (sPGA) score of 0 (clear) or 1 (almost clear). Patients with …

Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites

Y He, Z Luo, PA Klekotka, VL Burnett, JR Halpert - Biochemistry, 1994 - ACS Publications
Revised Manuscript Received December 21, 1993® abstract: Twelve site-directed mutants
of rat cytochrome P450 2B1 distributed over seven positions and four putative substrate …

Mammary epithelial cell-cycle progression via the α2β1 integrin: unique and synergistic roles of the α2 cytoplasmic domain

PA Klekotka, SA Santoro, A Ho, SF Dowdy… - The American journal of …, 2001 - Elsevier
The α 2 β 1 integrin supports cell-cycle progression of mammary epithelial cells adherent to
type I collagen matrices. Integrin collagen receptors containing the α 2 cytoplasmic domain …

[HTML][HTML] Measurement properties of the psoriasis symptom inventory electronic daily diary in patients with moderate to severe plaque psoriasis

…, K Gordon, H Wilson, H Zhang, PA Klekotka… - Value in Health, 2017 - Elsevier
Objectives The Psoriasis Symptom Inventory (PSI) is a patient-reported outcome instrument
that measures the severity of psoriasis signs and symptoms. This study evaluated …