Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin
OS Bains, TA Grigliatti, RE Reid, KW Riggs - Journal of Pharmacology and …, 2010 - ASPET
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however,
considerable interpatient variability exists in their pharmacokinetics. This may be caused by …
considerable interpatient variability exists in their pharmacokinetics. This may be caused by …
Respiratory and sleep effects of remifentanil in volunteers with moderate obstructive sleep apnea
…, MK Lee, SB McDonald, OS Bains - The Journal of the …, 2009 - pubs.asahq.org
Background There is concern that opioid-based analgesia will worsen sleep-related
respiratory insufficiency in patients with obstructive sleep apnea (OSA), resulting in serious …
respiratory insufficiency in patients with obstructive sleep apnea (OSA), resulting in serious …
A correlation between cytotoxicity and reductase-mediated metabolism in cell lines treated with doxorubicin and daunorubicin
OS Bains, A Szeitz, JM Lubieniecka, GE Cragg… - … of Pharmacology and …, 2013 - ASPET
… This work was carried out in partial fulfillment of OSB’s Ph.D. thesis titled: Bains (2010)
Altered metabolism of daunorubicin and doxorubicin by genetic variants of human aldo-keto and …
Altered metabolism of daunorubicin and doxorubicin by genetic variants of human aldo-keto and …
Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin
OS Bains, MJ Karkling, TA Grigliatti, RE Reid… - Drug Metabolism and …, 2009 - ASPET
… 6x-His-tagged proteins were purified using nickel-nitrilotriacetic acid (Ni-NTA) affinity
chromatography and elution with imidazole according to the procedure described in Bains et al. (…
chromatography and elution with imidazole according to the procedure described in Bains et al. (…
Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism
OS Bains, MJ Karkling, JM Lubieniecka… - … of Pharmacology and …, 2010 - ASPET
Doxorubicin (DOX) and daunorubicin (DAUN) are anthracycline anticancer agents; however,
considerable interpatient variability exists in their pharmacokinetics. This interpatient …
considerable interpatient variability exists in their pharmacokinetics. This interpatient …
Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin
OS Bains, RH Takahashi, TA Pfeifer, TA Grigliatti… - Drug metabolism and …, 2008 - ASPET
Aldo-keto reductases (AKRs) are a class of NADPH-dependent oxidoreductases that have
been linked to metabolism of the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)…
been linked to metabolism of the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)…
Energetic costs of pyrene metabolism in isolated hepatocytes of rainbow trout, Oncorhynchus mykiss
OS Bains, CJ Kennedy - Aquatic toxicology, 2004 - Elsevier
The respiratory costs of pyrene exposure and biotransformation were examined in isolated
hepatocytes of adult rainbow trout, Oncorhynchus mykiss. Baseline oxygen consumption …
hepatocytes of adult rainbow trout, Oncorhynchus mykiss. Baseline oxygen consumption …
Alterations in respiration rate of isolated rainbow trout hepatocytes exposed to the P-glycoprotein substrate rhodamine 123
OS Bains, CJ Kennedy - Toxicology, 2005 - Elsevier
Reducing intracellular xenobiotic concentration is an important defence strategy used by
cells challenged with foreign chemicals. One mechanism used to achieve this goal is via the …
cells challenged with foreign chemicals. One mechanism used to achieve this goal is via the …
Functional and energetic characterization of P-gp-mediated doxorubicin transport in rainbow trout (Oncorhynchus mykiss) hepatocytes
JL Hildebrand, OS Bains, DSH Lee… - … and Physiology Part C …, 2009 - Elsevier
An assessment of energetic costs associated with P-glycoprotein (P-gp)-mediated xenobiotic
efflux is important in understanding the energy budgets, tradeoffs, and fitness of organisms …
efflux is important in understanding the energy budgets, tradeoffs, and fitness of organisms …
Validation of a sequential extraction and liquid chromatography–tandem mass spectrometric method for determination of dihydrotestosterone, androstanediol and …
HH Adomat, OS Bains, JM Lubieniecka… - … of Chromatography B, 2012 - Elsevier
Androgens are key mediators of prostate development and function, a role that extends to
the development of prostate diseases such as benign prostatic hyperplasia (BPH) and …
the development of prostate diseases such as benign prostatic hyperplasia (BPH) and …