Oral dosages of 107 synthetic and natural flavourings and structurally-related compounds
were administered by intubation to the mouse, rat or guinea-pig. Animals were observed …

The subacute and/or chronic toxicity of 48 food flavourings was studied in rats. The toxicity
of five of these flavourings (coumarin, 6-methylcoumarin, dihydrocoumarin, methyl salicylate …

3. 4. 5. fast-growing period of the first three months on the ex-perimental diet. When the rats
on these higher dosage levels became adult, they were short, chubby, and very fat. They …

In the September, 1949 issue of the Food Drug Cosmetic Law Quarterly there appeared an
article entitled" Procedures for the Appraisal of the Toxicity of Chemicals in Foods." The article…

Safrole is an ingredient of sassafras and of a number of essential oils. It was added at 100,
500, 1000 or 5000 ppm to Purina pellets given to Osborne Mendel rats from weaning. …

Dihydrosafrole on chronic feeding produced benign and malignant esophageal tumors.
Safrole is a hepatic carcinogen. Liver changes produced by isosafrole, safrole, and …

An evaluation of toxicity by injection of the chemical into the yolk sac of fertile eggs prior to
incubation gave the following results:. Water, propylene glycol, corn oil, peanut oil, isotonic …

In rats fed diets containing from 100 to 800 ppm DDT for a period of 2 years, the following
effects were noted. 1. DDT produced chronic toxicity in rats at all concentrations. 2. The …

Data are presented to show up to 50-fold potentiation in the acute toxicity of EPN and malathion
if they are administered simultaneously to dogs. The potentiation is marked but less for …

Brilliant Blue FCF (FD & C Blue No. 1) and Indigotine (FD & C Blue No. 2) were fed to groups
of 24 Osborne-Mendel rats for two years at dietary levels of 0.5, 1.0, 2.0, and 5.0%. Growth …