… Imipramine N-oxide and nicotinamide N-oxide were reduced to imipramine and nicotinamide,
respectively, under anaerobic conditions by liver cytosol of rabbits, rats, mice, hamsters, …

… n = 88 metastases; n = 7 bone metastases among the 88 metastases in total. Pearson
correlation. b, Flow cytometry analysis of levels of ROR1 in tumours and matched metastases of …

… -cyclopropyl indazole analogue, compound 94, designed to improve pharmacokinetics,
largely mitigates N dealkylation observed and retains potent binding activity (MLLT1 K d 0.058 μ…

We have examined the glucuronidation of psilocin, a hallucinogenic indole alkaloid, by the
19 recombinant human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A, and 2B. …

… Thus, by sorting a set of predictions by their uncertainties and removing n-% of entries, we
expect that the overall prediction error of the subset will decrease. This is shown in Figure 6a …

… , is mainly metabolized in humans by N-glucuronidation. Enzyme studies, using the (then) …
compound, particularly when there is a possibility of N-glucuronidation. Moreover, this study …

Although skin is the largest organ of the human body, cutaneous drug metabolism is often
overlooked, and existing experimental models are insufficiently validated. This proof-of-…

While high lipophilicity tends to improve potency, its effects on pharmacokinetics (PK) are
complex and often unfavorable. To predict clinical PK in early drug discovery, we built human …

The human UDP-glucuronosyltransferase (UGT) enzymes UGT1A9 and UGT2B7 play
important roles in the hepatic glucuronidation of many drugs. The presence of bovine serum …

… All incubations were performed in at least two replications (n = 2−6), with midazolam as a …
The f u,inc values were measured by RED for all test compounds (n = 32) in permeabilized …