Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite

N Makkonen, A Salminen, MJ Rogers, JC Frith… - European journal of …, 1999 - Elsevier
Clodronate (dichloromethylidene-bisphosphonate), a halogen-containing bisphosphonate,
can inhibit the release of cytokines from RAW 264 macrophages and has anti-inflammatory …

Obstetric prognosis in second pregnancy after preeclampsia in first pregnancy

N Makkonen, S Heinonen, P Kirkinen - Hypertension in pregnancy, 2000 - Taylor & Francis
… Mothers without preeclampsia in their first and second pregnancies (N = 2806) were
used as the reference group. Pregnancy outcome measures of women with a history of …

Poverty remittances in Lesotho

B Gustafsson, N Makonnen - Journal of African Economies, 1993 - academic.oup.com
The study estimates the extent and structure of poverty in Lesotho, based on a recent
Household Budget Survey, using additive decomposable poverty indices. A special feature of …

The cellular uptake and metabolism of clodronate in RAW 264 macrophages

H Mönkkönen, MJ Rogers, N Makkonen, S Niva… - Pharmaceutical …, 2001 - Springer
… Although earlier data strongly suggest that clodronate and other non-N-BPs act as the
prodrugs, the active form being the metabolite AppCCl2pp, nothing is known on the time course …

Postpartum recovery after severe pre-eclampsia and HELLP-syndrome

N Makkonen, M Harju, P Kirkinen - 1996 - degruyter.com
… Le retablissement post dans les cas de syndrome de HELLP n'a pas presente de difference
… -uterine apres Γ accouchement mais cette prediction n'etait pas valable pour les autres fac…

Streptomyces spores from mouldy houses induce nitric oxide, TNFα and IL-6 secretion from RAW264. 7 macrophage cell line without causing subsequent cell death

MR Hirvonen, A Nevalainen, N Makkonen… - Environmental …, 1997 - Elsevier
The current view is that only bacterial lipopolysaccharide (LPS) and gamma interferon (IFNγ)
are able to alone activate macrophages to secrete nitric oxide (NO), probably a causative …

Apolipoprotein E alleles in women with pre-eclampsia

N Makkonen, S Heinonen, M Hiltunen… - Journal of clinical …, 2001 - jcp.bmj.com
… (n = 91) and pregnant women with a diagnosis of pre-eclampsia (n = 133). In addition, the
frequencies of the alleles in the general population in this area are presented for comparison. …

Induced production of nitric oxide, tumor necrosis factor, and interleukin-6 in RAW 264.7 macrophages by streptomycetes from indoor air of moldy houses

MR Hirvonen, A Nevalainen, N Makkonen… - Archives of …, 1997 - Taylor & Francis
Dampness and mold growth in buildings cause spore generation into indoor air, which is
associated with respiratory tract disorders. Specific agents or cellular mechanisms of diseases …

Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro.

N Makkonen, MR Hirvonen, T Teräväinen… - … of Pharmacology and …, 1996 - ASPET
The macrophage-suppressive properties of three bisphosphonates were evaluated by studying
their effect on nitric oxide (NO) production by activated RAW 264 macrophage-like cells. …

The effect of free gallium and gallium in liposomes on cytokine and nitric oxide secretion from macrophage-like cells in vitro

N Makkonen, MR Hirvonen, K Savolainen… - Inflammation …, 1995 - Springer
The aim of this study was to evaluate the effect of gallium nitrate, gallium-nitrilotriacetate (NTA)
complex, and liposomal gallium-NTA on IL-6, TNFα, and nitric oxide (NO) release from …