User profiles for N. Legrand

Nicolas Legrand

Aarhus University
Verified email at cfin.au.dk
Cited by 219

[PDF][PDF] Humanized mice for modeling human infectious disease: challenges, progress, and outlook

N Legrand, A Ploss, R Balling, PD Becker, C Borsotti… - Cell host & …, 2009 - cell.com
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency
virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we …

Experimental models to study development and function of the human immune system in vivo

N Legrand, K Weijer, H Spits - The Journal of Immunology, 2006 - journals.aai.org
… Interestingly, we observed that human T cells in HIS (BALB-Rag/γ) mice also display a
high turnover rate and are prone to apoptosis (N. Legrand, et al., submitted for publication), …

Anti-inflammatory and anticancer drugs from nature

B Orlikova, N Legrand, J Panning, M Dicato… - Advances in nutrition …, 2014 - Springer
N unmodified natural products, ND derived from a natural product—usually after semisynthetic
modification of the natural product, NB a natural botanical-defined mixture approved as …

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

…, HS Hreggvidsdottir, SE Heinsbroek, N Legrand… - Nature …, 2013 - nature.com
Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling.
Recently identified ILC populations have a cytokine expression pattern that resembles …

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

ND Huntington, N Legrand, NL Alves, B Jaron… - Journal of Experimental …, 2009 - rupress.org
The in vivo requirements for human natural killer (NK) cell development and differentiation
into cytotoxic effectors expressing inhibitory receptors for self–major histocompatability …

Homeostasis of peripheral CD4+ T cells: IL-2Rα and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

ARM Almeida, N Legrand, M Papiernik… - The Journal of …, 2002 - journals.aai.org
We show that the lymphoid hyperplasia observed in IL-2Rα-and IL-2-deficient mice is due to
the lack of a population of regulatory cells essential for CD4 T cell homeostasis. In chimeras …

Physical characterization of the charging process of a Li-ion battery and prediction of Li plating by electrochemical modelling

N Legrand, B Knosp, P Desprez, F Lapicque… - Journal of Power …, 2014 - Elsevier
This paper deals with occurrence of lithium plating on the negative electrode of lithium-ion
batteries, a significant ageing phenomenon known to damage lithium-ion battery …

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T-and natural killer-(NK) cell homeostasis in vivo

N Legrand, ND Huntington… - Proceedings of the …, 2011 - National Acad Sciences
… The number of human GFP + T cells recovered from the spleen of the recipient mice is
plotted as a percentage of recovery from the initial inoculum (n = 4 control vs. n = 3 mCD47 per …

High-throughput identification of antigen-specific TCRs by TCR gene capture

…, R Gomez-Eerland, L Jahn, P Hombrink, N Legrand… - Nature medicine, 2013 - nature.com
… the clonal pMHC multimer + T cell populations that were analyzed was 100% (n = 113). … In
all cases tested (n = 14), TCR-transduced CD8 + T cells stained positive with pMHC multimers …

Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- γc-/- mice: functional inactivation of p53 in …

…, K Weijer, A Voordouw, CH Uittenbogaart, N Legrand… - Blood, 2004 - ashpublications.org
Tumor suppressor p53 plays an important role in regulating cell cycle progression and
apoptosis. Here we applied RNA interference to study the role of p53 in human hematopoietic …