Interstitial lung diseases (ILDs) are a diverse group of pulmonary disorders characterized by
various patterns of inflammation and fibrosis in the interstitium of the lung. Because injury …

Immune and neuroendocrine systems have bidirectional communications. Growth hormone
(GH) and an orexigenic hormone ghrelin are expressed in various immune cells such as T …

Three genes commonly causing Charcot–Marie–Tooth disease (CMT) encode myelin‐related
proteins: peripheral myelin protein 22 (PMP22), myelin protein zero (MPZ) and connexin …

Parkinson's disease is a common neurodegenerative disease with complex clinical features
1 . Autosomal recessive juvenile parkinsonism (AR-JP) 2 , 3 maps to the long arm of …

… (+)FLAG vector, we ligated oligo DNAs encoding N-terminal Myc and the FLAG epitope
to the KpnI/BamHI site of pcDNA3.1(+) (Invitrogen). We amplified the cDNAs of wild-type or …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Recent identification
of genes linked to familial forms of PD such as Parkin and PINK1 (PTEN-induced putative …

To identify susceptibility variants for Parkinson's disease (PD), we performed a genome-wide
association study (GWAS) and two replication studies in a total of 2,011 cases and 18,381 …

… will lead to accumulation of αSp22 n in ARPD (step 2b) and lack of αSp22-Ub n formation. …
Some of these αSp22-Ub n –conjugates are not efficiently processed by proteasomal …

A putative G protein-coupled transmembrane polypeptide, named Pael receptor, was identified
as an interacting protein with Parkin, a gene product responsible for autosomal recessive …

There is growing evidence that oxidative stress and mitochondrial respiratory failure with
attendant decrease in energy output are implicated in nigral neuronal death in Parkinson …