[HTML][HTML] Calcitonin gene-related peptide pre-administration acts as a novel antidepressant in stressed mice
N Hashikawa-Hobara, T Ogawa, Y Sakamoto… - Scientific reports, 2015 - nature.com
… (C) Sucrose preferences and total fluid intake in the sucrose preference test (saline n = 5,
CGRP n = 5). No treatment significantly affected general behavior, locomotor activity, rearing …
CGRP n = 5). No treatment significantly affected general behavior, locomotor activity, rearing …
Role of Heat Shock Transcription Factor in Saccharomyces cerevisiae Oxidative Stress Response
A Yamamoto, J Ueda, N Yamamoto, N Hashikawa… - Eukaryotic …, 2007 - Am Soc Microbiol
The heat shock transcription factor Hsf1 of the yeast Saccharomyces cerevisiae regulates
the transcription of a set of genes that contain heat shock elements (HSEs) in their promoters …
the transcription of a set of genes that contain heat shock elements (HSEs) in their promoters …
Phosphorylation of the yeast heat shock transcription factor is implicated in gene-specific activation dependent on the architecture of the heat shock element
N Hashikawa, H Sakurai - Molecular and Cellular Biology, 2004 - Taylor & Francis
… We then analyzed the physical interaction between the N-terminal regulatory region and
the C-terminal AR2-CTM domains of ScHsf1 by GST pull-down assay (Fig. 6 ). The C-terminal …
the C-terminal AR2-CTM domains of ScHsf1 by GST pull-down assay (Fig. 6 ). The C-terminal …
HSP105 prevents depression-like behavior by increasing hippocampal brain-derived neurotrophic factor levels in mice
N Hashikawa, Y Utaka, T Ogawa, R Tanoue… - Science …, 2017 - science.org
… (E) Western blotting of BDNF protein expression in mouse hippocampus (n = 4 to 5 animals
per group). Each bar indicates the mean ± SEM, with significant differences shown as inserts …
per group). Each bar indicates the mean ± SEM, with significant differences shown as inserts …
[HTML][HTML] Lactobacillus paragasseri OLL2809 Improves Depression-Like Behavior and Increases Beneficial Gut Microbes in Mice
N Hashikawa-Hobara, A Otsuka, C Okujima… - Frontiers in …, 2022 - frontiersin.org
Lactobacillus paragasseri OLL2809 is a probiotic bacterial strain isolated from healthy human
feces. While OLL2809 has been studied for its immunomodulatory activities, its effect on …
feces. While OLL2809 has been studied for its immunomodulatory activities, its effect on …
Candesartan cilexetil improves angiotensin II type 2 receptor–mediated neurite outgrowth via the PI3K-Akt pathway in fructose-induced insulin-resistant rats
N Hashikawa-Hobara, N Hashikawa, Y Inoue… - Diabetes, 2012 - Am Diabetes Assoc
We have shown previously that stimulation of the angiotensin II type 2 receptor (AT 2 R)
results in nerve facilitation. In this study, we determined the capacity of candesartan to correct …
results in nerve facilitation. In this study, we determined the capacity of candesartan to correct …
[HTML][HTML] Different mechanisms are involved in the transcriptional activation by yeast heat shock transcription factor through two different types of heat shock elements
N Hashikawa, N Yamamoto, H Sakurai - Journal of biological chemistry, 2007 - ASBMB
The hydrophobic repeat is a conserved structural motif of eukaryotic heat shock transcription
factor (HSF) that enables HSF to form a homotrimer. Homotrimeric HSF binds to heat shock …
factor (HSF) that enables HSF to form a homotrimer. Homotrimeric HSF binds to heat shock …
[HTML][HTML] Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice
N Hashikawa-Hobara, A Otsuka, R Ishikawa… - Biomedicine & …, 2019 - Elsevier
It is well known that chamomile is one of the oldest known medicinal herbs and has been
used to treat various disorders, but it is mainly German chamomile. The effects of Roman …
used to treat various disorders, but it is mainly German chamomile. The effects of Roman …
[HTML][HTML] Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis
N Hashikawa, M Ido, Y Morita… - Scientific Reports, 2021 - nature.com
Heat shock proteins (HSPs) are molecular chaperones that repair denatured proteins. The
relationship between HSPs and various diseases has been extensively studied. However, the …
relationship between HSPs and various diseases has been extensively studied. However, the …
[HTML][HTML] Hyperinsulinemia induces hypertension associated with neurogenic vascular dysfunction resulting from abnormal perivascular innervations in rat mesenteric …
…, P Tangsucharit, X Jin, N Hashikawa… - Hypertension …, 2011 - nature.com
We previously reported that chronic hyperinsulinemia and insulin resistance induced by
fructose-drinking loading elicited hypertension associated with abnormal neuronal regulation of …
fructose-drinking loading elicited hypertension associated with abnormal neuronal regulation of …