Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2-and P-glycoprotein-mediated transport

M Yamazaki, B Li, SW Louie, NT Pudvah, R Stocco… - Xenobiotica, 2005 - Taylor & Francis
The effects of different fibric acid derivatives (bezafibrate, clofibrate, clofibric acid, fenofibrate,
fenofibric acid and gemfibrozil) on human organic anion transporting-polypeptide 1B1 (…

Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist

…, CP Regan, JF Fay, YS Tang, CC Li, NT Pudvah… - … of Pharmacology and …, 2010 - ASPET
Calcitonin gene-related peptide (CGRP) has long been hypothesized to play a key role in
migraine pathophysiology, and the advent of small-molecule antagonists has clearly …

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

…, GR Seabrook, DJ Hazuda, NT Pudvah… - Bioorganic & medicinal …, 2007 - Elsevier
This Letter describes the design and synthesis of tertiary carbinamine macrocyclic inhibitors
of the β-secretase (BACE-1) enzyme. These macrocyclic inhibitors, some of which …

Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates

…, M Patel, SY Pechenov, T Pei, NT Pudvah… - Journal of controlled …, 2014 - Elsevier
The greatest challenge standing in the way of effective in vivo siRNA delivery is creating a
delivery vehicle that mediates a high degree of efficacy with a broad therapeutic window. Key …

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists

…, EL Moore, SD Mosser, NT Pudvah… - Bioorganic & medicinal …, 2006 - Elsevier
A rapid analogue approach to identification of spirohydantoin-based CGRP antagonists
provided novel, low molecular weight leads. Modification of these leads afforded a series of …

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors

…, S Sankaranarayanan, AJ Simon, NT Pudvah… - Bioorganic & medicinal …, 2007 - Elsevier
This letter describes replacements for the P3 amide moiety present in previously reported
tertiary carbinamine macrolactones. Although P-gp efflux issues associated with these amide-…

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

C Tang, Y Kuo, NT Pudvah, JD Ellis… - Biochemical …, 2009 - Elsevier
Brain penetration of drugs which are subject to P-glycoprotein (Pgp)-mediated efflux is
attenuated, as manifested by the fact that the cerebrospinal fluid concentration (C CSF ), a good …

An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents

…, AM Leone, M Patel, S Pechenov, NT Pudvah… - International journal of …, 2014 - Elsevier
A series of amphiphilic, biodegradable polypeptide copolymers were prepared for the
delivery of siRNA (short interfering ribonucleic acid). The molecular weight (or polymer chain …

Renal elimination of a novel and potent αvβ3 integrin antagonist in animals

T Prueksaritanont, JH Hochman, Y Meng, NT Pudvah… - Xenobiotica, 2004 - Taylor & Francis
Compound A (3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]napthyridin-2-yl)propyl]-imidazolidin-1-yl}-3(S)-(6-methoxy-pyridin-3-yl)propionic
acid), a hydrophilic zwitterion, is a potent and …

[PDF][PDF] Pharmacological Properties of MK-3207 [2-[(8R)-8-(3, 5-difluorophenyl)-10-oxo-6, 9-diazaspiro [4.5] dec-9-yl]-N-[(2R)-2'-oxo-1, 1', 2', 3-tetrahydrospiro [indene-2 …

…, JF Fay, YS Tang, CC Li, NT Pudvah… - … of Pharmacology and …, 2010 - Citeseer
Calcitonin gene-related peptide (CGRP) has long been hypothesized to play a key role in
migraine pathophysiology and the advent of small molecule antagonists have clearly …