MicroRNAs are endogenous repressors of gene expression. We examined microRNAs in
the renal medulla of Dahl salt-sensitive rats and consomic SS-13 BN rats. Salt-induced …

Padmanabhan et al Uromodulin and Blood Pressure 919 and, depending on its glycosylation
status, migrates as an 80-to 90-kDa band on SDS-PAGE. Cleavage is necessary for …

The function of the nephron, the anatomical unit of the kidney, is segmented; at least 12
segments have been identified that differ in their morphology, transport properties and hormonal …

The levels of leukotriene C 4 (LTC 4 ), leukotriene B 4 (LTB 4 ), prostaglandin E 2 (PGE 2 ),
and histamine were measured in nasal lavage fluids obtained from aspirin-sensitive, …

A recent genome-wide association study identified a locus on chromosome 16 in the promoter
region of the uromodulin (UMOD) gene that is associated with hypertension. Here, we …

The effects of angiotensin II (ANG II) on tumor necrosis factor-α (TNF) production were
determined in freshly isolated tubules from the medullary thick ascending limb (MTAL). ANG II (10 …

TNF-α (tumor necrosis factor-alpha) is the best known as a proinflammatory cytokine; yet, this
cytokine also has important immunomodulatory and regulatory functions. As the effects of …

Tumor necrosis factor-α (TNF-α) and angiotensin II (Ang II) induced a transient increase in
vascular smooth muscle cell (VSMC) cyclooxygenase-2 (COX-2) mRNA accumulation, without …

Intraventricular haemorrhage is a major complication of prematurity that results in neurological
dysfunctions, including cerebral palsy and cognitive deficits. No therapeutic options are …

Hypertension (HTN), a major public health issue is currently the leading factor in the global
burden of disease, where associated complications account for 9.4 million deaths worldwide …