IRAK1: a critical signaling mediator of innate immunity

S Gottipati, NL Rao, WP Fung-Leung - Cellular signalling, 2008 - Elsevier
… have also observed a partial reduction in IL-6 and TNF-α produced by IRAK1-deficient
peritoneal macrophages as well as splenocytes when stimulated with TLR7 or TLR9 ligands (Rao

TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders

L Karlsson, S Sun, NL Rao, J Venable… - … & Allergy-Drug …, 2007 - ingentaconnect.com
There is an increasing interest in ligands of nucleic acid-sensing Toll-like receptors (TLR),
especially TLR7 and TLR9, for pharmacological intervention in various diseases. The TLR7 …

[HTML][HTML] Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis

…, R Iyer, K Sheth, O Sharpe, NL Rao… - Nature …, 2023 - nature.com
The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis
(RA) remain poorly defined. Although increased levels of CD8 + T cells have been …

[HTML][HTML] Receptor for advanced glycation end product, organ crosstalk, and pathomechanism targets for comprehensive molecular therapeutics in diabetic ischemic …

NL Rao, GB Kotian, JK Shetty, BP Shelley, MK Dmello… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus, a well-established risk factor for stroke, is related to higher mortality and
poorer outcomes following the stroke event. Advanced glycation end products(AGEs), their …

IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity

…, M Mori, S Pavlidis, IM Adcock, NL Rao… - Journal of Allergy and …, 2019 - Elsevier
Background Influenza virus triggers severe asthma exacerbations for which no adequate
treatment is available. It is known that IL-33 levels correlate with exacerbation severity, but its …

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton

NL Rao, PJ Dunford, X Xue, X Jiang… - … of Pharmacology and …, 2007 - ASPET
Leukotriene A 4 hydrolase (LTA 4 H) catalyzes production of the proinflammatory lipid
mediator, leukotriene (LT) B 4 , which is implicated in a number of inflammatory diseases. We …

Discrete prices and the incidence and efficiency of excise taxes

CT Conlon, NL Rao - American Economic Journal: Economic Policy, 2020 - aeaweb.org
This paper uses UPC-level data to examine the relationship between excise taxes, retail
prices, and consumer welfare in the distilled spirits market. We document a nominal rigidity in …

[HTML][HTML] Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis

…, VM Holers, R Iyer, EB Prideaux, NL Rao… - Nature …, 2023 - nature.com
Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA),
are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may …

Leukotriene A4 Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness

NL Rao, JP Riley, H Banie, X Xue, B Sun… - American journal of …, 2010 - atsjournals.org
Rationale: Allergic asthma is characterized by reversible airway obstruction, lung inflammation,
and airway hyperresponsiveness (AHR). Previous studies using leukotriene B 4 (LTB 4 ) …

An early innate response underlies severe influenza‐induced exacerbations of asthma in a novel steroid‐insensitive and anti‐IL‐5‐responsive mouse model

…, T Dekker, A Logiantara, IM Adcock, NL Rao… - Allergy, 2017 - Wiley Online Library
Background Acute worsening of asthma symptoms (exacerbation) is predominantly triggered
by respiratory viruses, with influenza causing the most severe exacerbations. The lack of …