The critical role of inflammatory processes in health and disease has long been recognized,
1 yet the detailed molecular mechanisms and biological events that regulate the …

The essential fatty acid eicosapentaenoic acid (EPA) present in fish oils displays beneficial
effects in a range of human disorders associated with inflammation including cardiovascular …

Celecoxib is an NSAID that was developed as a selective inhibitor of COX-2 and approved
by the FDA for the treatment of various forms of arthritis and the management of acute or …

… Petasis was born in Cyprus and received his undergraduate education at the Aristotelian
University of Thessaloniki in Greece. In 1979 he joined the research group of Professor KC …

We report herein an alternative and more practical titanium-mediated methylenation that avoids
some difficulties10 associated with 2 and 3, particularly for routine synthetic applications. …

Endogenous mechanisms that act in the resolution of acute inflammation are essential for
host defense and the return to homeostasis. Resolvin D1 (RvD1), biosynthesized during …

Lipoxins (LX) are lipoxygenase-derived eicosanoids generated during inflammation. LX inhibit
polymorphonuclear neutrophil (PMN) chemotaxis and adhesion and are putative braking …

A growing body of evidence indicates that resolution of acute inflammation is an active
process 1 , 2 . Resolvins are a new family of lipid mediators enzymatically generated within …

Resolvin E1 (RvE1; 5S,12R,18R-trihydroxyeicosapentaenoic acid) is an antiinflammatory lipid
mediator derived from omega-3 fatty acid eicosapentaenoic acid (EPA). At the local site of …

In recent years there has been an increasing interest for new practical methods to prepare
novel non-natural R-amino acid derivatives to serve as building blocks in combinatorial …