User profiles for M. Z. Leonard

Michael Z. Leonard

Vanderbilt University
Verified email at vanderbilt.edu
Cited by 332

[HTML][HTML] Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF

EL Newman, MZ Leonard, DT Arena… - Neurobiology of …, 2018 - Elsevier
Both the ostensibly aversive effects of unpredictable episodes of social stress and the intensely
rewarding effects of drugs of abuse activate the mesocorticolimbic dopamine systems. …

[HTML][HTML] Translational models of adaptive and excessive fighting: an emerging role for neural circuits in pathological aggression

HE Covington III, EL Newman, MZ Leonard… - …, 2019 - ncbi.nlm.nih.gov
Aggression is a phylogenetically stable behavior, and attacks on conspecifics are observed
in most animal species. In this review, we discuss translational models as they relate to …

D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning

JE Zachry, MG Kutlu, HJ Yoon, MZ Leonard, M Chevée… - Neuron, 2024 - cell.com
At the core of value-based learning is the nucleus accumbens (NAc). D1- and D2-receptor-containing
medium spiny neurons (MSNs) in the NAc core are hypothesized to have …

Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking

…, A Godino, EG Peck, JP Sens, MZ Leonard… - …, 2024 - nature.com
Cocaine use disorder represents a public health crisis with no FDA-approved medications
for its treatment. A growing body of research has detailed the important connections between …

Don't ditch the laptop just yet: A direct replication of Mueller and Oppenheimer's (2014) study 1 plus mini meta-analyses across similar studies

…, CS Crittle, VA Floerke, MZ Leonard… - Psychological …, 2021 - journals.sagepub.com
In this direct replication of Mueller and Oppenheimer’s (2014) Study 1, participants watched
a lecture while taking notes with a laptop (n = 74) or longhand (n = 68). After a brief …

Comparisons of Δ9-tetrahydrocannabinol and anandamide on a battery of cognition-related behavior in nonhuman primates

BD Kangas, MZ Leonard, VG Shukla… - … of Pharmacology and …, 2016 - ASPET
The primary psychoactive ingredient of marijuana, Δ 9 -tetrahydrocannabinol (Δ 9 -THC),
has medicinal value but also produces unwanted deleterious effects on cognitive function, …

Novel C-ring-hydroxy-substituted controlled deactivation cannabinergic analogues

…, S Jiang, CA Paronis, MZ Leonard… - Journal of medicinal …, 2016 - ACS Publications
In pursuit of safer controlled-deactivation cannabinoids with high potency and short duration
of action, we report the design, synthesis, and pharmacological evaluation of novel C9- and …

Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of …

…, VMM Ferreira, E Kenneally, MZ Leonard… - …, 2022 - Springer
Rationale The attraction to alcohol can be greatly increased when it is consumed in a social
context. While pro-social interactions can potentiate voluntary alcohol drinking under some …

Food restriction level and reinforcement schedule differentially influence behavior during acquisition and devaluation procedures in mice

M Chevée, CJ Kim, N Crow, EG Follman, MZ Leonard… - Eneuro, 2023 - eneuro.org
Behavioral strategies are often classified based on whether reinforcer value controls
reinforcement. Value-sensitive behaviors, in which animals update their actions when reinforcer …

Escalated cocaine “binges” in rats: enduring effects of social defeat stress or intra-VTA CRF

MZ Leonard, JF DeBold, KA Miczek - Psychopharmacology, 2017 - Springer
Rationale Exposure to intermittent social defeat stress elicits corticotropin releasing factor (CRF)
release into the VTA and induces long-term modulation of mesocorticolimbic dopamine …