Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate …
…, C Müller, O Nayler, C Qiu, M Rey, MW Scherz… - … of Pharmacology and …, 2004 - ASPET
Urotensin-II (U-II) is a cyclic peptide now described as the most potent vasoconstrictor known.
U-II binds to a specific G protein-coupled receptor, formerly the orphan receptor GPR14, …
U-II binds to a specific G protein-coupled receptor, formerly the orphan receptor GPR14, …
New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 1. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and …
…, PA Young, JM Ridgeway, MW Scherz… - Journal of medicinal …, 1998 - ACS Publications
A series of 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs)
were prepared and evaluated as potential nonsteroidal antiinflammatory and analgesic …
were prepared and evaluated as potential nonsteroidal antiinflammatory and analgesic …
Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous …
BG Campbell, MW Scherz, JF Keana… - Journal of …, 1989 - Soc Neuroscience
Sigma receptors are specific, highly localized binding sites in limbic and sensorimotor
structures of the brain that interact with many psychotropic drugs. These agents include the …
structures of the brain that interact with many psychotropic drugs. These agents include the …
Synthesis and structure-activity relationships of N, N'-di-o-tolylguanidine analogs, high-affinity ligands for the haloperidol-sensitive. sigma. receptor
MW Scherz, M Fialeix, JB Fischer… - Journal of medicinal …, 1990 - ACS Publications
With an eye toward the development of novel atypical antipsychotic agents, we have studied
the structure-affinity relationships of,'-di-o-tolylguanidine (DTG, 3) and its congeners at the …
the structure-affinity relationships of,'-di-o-tolylguanidine (DTG, 3) and its congeners at the …
Synthesis and characterization of a series of diarylguanidines that are noncompetitive N-methyl-D-aspartate receptor antagonists with neuroprotective properties.
JF Keana, RN McBurney, MW Scherz… - Proceedings of the …, 1989 - National Acad Sciences
Four diarylguanidine derivatives were synthesized. These compounds were found to displace,
at submicromolar concentrations, 3H-labeled 1-[1-(2-thienyl)cyclohexyl]piperidine and (+)-…
at submicromolar concentrations, 3H-labeled 1-[1-(2-thienyl)cyclohexyl]piperidine and (+)-…
Urotensin II mediates ERK1/2 phosphorylation and proliferation in GPR14-transfected cell lines
…, C Mueller, B Haenig, MW Scherz… - Journal of Receptors …, 2002 - Taylor & Francis
Urotensin-II (U-II), a vasoactive cyclic neuropeptide, was recently identified as the natural
ligand for the G-protein coupled receptor GPR14. The expression pattern of U-II and GPR14 …
ligand for the G-protein coupled receptor GPR14. The expression pattern of U-II and GPR14 …
Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl [6-3H] phenyl)-3-(2-methyl [4, 6-3H] phenyl) …
…, BC Tester, MW Scherz… - Proceedings of the …, 1988 - National Acad Sciences
… Molecular weight standards were tryptophan, carbonic anhydrase (29 kDa), bovine serum
albumin (66kDa), alcohol dehydrogenase (150 kDa), apoferritin (443 kDa), and blue dextran (…
albumin (66kDa), alcohol dehydrogenase (150 kDa), apoferritin (443 kDa), and blue dextran (…
New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 3. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and …
…, PA Young, JM Ridgeway, MW Scherz… - Journal of medicinal …, 1998 - ACS Publications
We report an expansion of the scope of our initial discovery that 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans
(DHDMBFs) are antiinflammatory and analgesic …
(DHDMBFs) are antiinflammatory and analgesic …
Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels
ICH Yang, MW Scherz, A Bahinski, PB Bennett… - … of Pharmacology and …, 2000 - ASPET
Selective inhibitors of the slow component of the cardiac delayed rectifier K + current, I Ks ,
are of interest as novel class III antiarrhythmic agents and as tools for studying the physiologic …
are of interest as novel class III antiarrhythmic agents and as tools for studying the physiologic …
A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin
…, M Maresca, L Micheli, C Farina, MW Scherz… - Cancer Chemotherapy …, 2017 - Springer
Background and aim The FOLFOX family of chemotherapy regimens are hampered by the
development of a painful neuropathy. Current clinical treatments are inadequate, and …
development of a painful neuropathy. Current clinical treatments are inadequate, and …