[HTML][HTML] Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin

…, NY Kedishvili, TL Abraham, MR Brzezinski… - Journal of Biological …, 1997 - ASBMB
… Km of hCE-1 for cocaine are from Brzezinski et al. (2) was determined with the ethyl …
Km of hCE-1 for cocaine are from Brzezinski et al. (2) was determined with the ethyl …

[PDF][PDF] Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases.

LM Kamendulis, MR Brzezinski, EV Pindel… - Journal of pharmacology …, 1996 - Citeseer
Concomitant iv use of cocaine and heroin(“speedballing”) is prevalent among drug-abusing
populations. Heroin is rapidly metabolized by sequential deacetylation of two separate ester …

Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from …

MR Brzezinski, TL Abraham, CL Stone, RA Dean… - Biochemical …, 1994 - Elsevier
The psychomotor stimulant cocaine is inactivated primarily by hydrolysis to benzoylecgonine,
the major urinary metabolite of the drug. A non-specific carboxylesterase was purified from …

Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs

MR Brzezinski, BJ Spink, RA Dean, CE Berkman… - Drug Metabolism and …, 1997 - ASPET
Purified human liver carboxylesterase (hCE-1) catalyzes the hydrolysis of cocaine to form
benzoylecgonine, the deacetylation of heroin to form 6-acetylmorphine, and the ethanol-…

Catalytic activity and quantitation of cytochrome P-450 2E1 in prenatal human brain

MR Brzezinski, H Boutelet-Bochan, RE Person… - … of Pharmacology and …, 1999 - ASPET
Cytochrome P-450 2E1 (CYP2E1) is a readily inducible hemoprotein that catalyzes the
oxidation of endogenous compounds and many low molecular weight xenobiotics. As the major …

[PDF][PDF] Effects of ethanol on cocaine metabolism and disposition in the rat

…, WF Bosron, FM Zachman, J Zhang, MR Brzezinski - NIDA Res Monogr, 1997 - s2.bitdl.ir
Abuse of cocaine in combination with other drugs is a widespread practice (Washton and
Gold 1987) and the coabuse of alcohol is particularly common, with 99 percent of cocaine …

Tissue distribution of cocaine methyl esterase and ethyl transferase activities: correlation with carboxylesterase protein.

RA Dean, J Zhang, MR Brzezinski, WF Bosron - Journal of Pharmacology …, 1995 - ASPET
The tissue distribution of cocaine methyl esterase and ethanol-dependent ethyl transferase
activities was determined in the rat and compared to the tissue distribution of three distinct …

[PDF][PDF] Human liver cocaine carboxylesterases

WF Bosron, RA Dean, MR Brzezinski… - NIDA Res Monogr, 1997 - researchgate.net
The stimulant effects of cocaine are relatively short lived, as evidenced by the increase in
heart rate that peaks at about 60 minutes after cocaine administration and declines thereafter (…

Inhibition of human prenatal biosynthesis of all-trans-retinoic acid by ethanol, ethanol metabolites, and products of lipid peroxidation reactions: a possible role for …

…, MR Brzezinski, H Chen, MR Juchau - Biochemical …, 1999 - Elsevier
Biotransformation of all-trans-retinol (t-ROH) and all-trans-retinal (t-RAL) to all-trans-retinoic
acid (t-RA) in human prenatal hepatic tissues (53–84 gestational days) was investigated …

Patterns of CYP26 expression in human prenatal cephalic and hepatic tissues indicate an important role during early brain development

…, MR Brzezinski, MR Juchau - Developmental Brain …, 2000 - Elsevier
CYP26 (P450RAI) catalyzes catabolic retinoic acid (RA) hydroxylation and thereby appears
to play a critical role in retinoid signaling pathways during development. In this study, a …