Development of a testing battery to assess chemical-induced immunotoxicity: National Toxicology Program's guidelines for immunotoxicity evaluation in mice

…, AE Munson, PT Thomas, MP Holsapple… - … and Applied Toxicology, 1988 - Elsevier
HOLSAPPLE,~JAMESD.FENTERS,$KIMBER L. WHITE,JR.,~ LLOYD D. … We have
modified the latter so that it may be successfully used in B6C3Fl mice using an [‘2SI]UdR …

Species comparison of anatomical and functional immune system development

MP Holsapple, LJ West… - Birth Defects Research …, 2003 - Wiley Online Library
… A subsequent panel discussion, with input from all participants, offered several important
conclusions (Holsapple, 2002a). Although rabbits were emphasized as a preferred animal …

A review of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update

MP Holsapple, NK Snyder, SC Wood, DL Morris - Toxicology, 1991 - Elsevier
2,3,7,8-tetrachlorodibenzo-p-dioxin, more popularly called or TCDD and referred to in this
reviews as 2,3,7,8-TCDD, is considered the prototype of the polychlorinated dibenzo-p-dioxins …

Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs

MP Holsapple, WH Farland, TD Landry… - Toxicological …, 2005 - academic.oup.com
This article summarizes a roundtable discussion held at the 2005 Society of Toxicology
Annual Meeting in New Orleans, LA. The purpose of the roundtable was to review the current …

Mode of action in relevance of rodent liver tumors to human cancer risk

MP Holsapple, HC Pitot, SH Cohen… - Toxicological …, 2006 - academic.oup.com
Hazard identification and risk assessment paradigms depend on the presumption of the
similarity of rodents to humans, yet species specific responses, and the extrapolation of high-…

2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: possible mechanisms

MP Holsapple, DL Morris, SC Wood… - Annual review of …, 1991 - annualreviews.org
… Similar results were observed using the Ab response to SRBC (Holsapple et ai, unpublished
observations). The suppression of the in vitro Ab response by 2,7-DCDD was in agreement …

Aryl hydrocarbon receptor-dependent suppression by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin of IgM secretion in activated B cells

CEW Sulentic, MP Holsapple, NE Kaminski - Molecular pharmacology, 1998 - ASPET
The immune system has been identified as a sensitive target for the toxic effects produced by
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Furthermore, the B cell has been identified as …

Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review

HG Haggerty, MP Holsapple - Toxicology, 1990 - Elsevier
… 58 DH Kim, KH Yang, KW Johnson and MP Holsapple, Role of … Page and MP Holsapple,
Suppression of humoral immune … 67 NE Kaminski and MP Holsapple, Inhibition of macrophage …

Oral bioaccessibility of dioxins/furans at low concentrations (50− 350 ppt toxicity equivalent) in soil

…, BD Landenberger, MP Holsapple - … science & technology, 2002 - ACS Publications
Animal studies have indicated that the oral bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) in environmentally contaminated soil could range from 0.5 to 60%. To estimate …

What's so special about the developing immune system?

…, SL Makris, GA Parker, MP Holsapple - … journal of toxicology, 2008 - journals.sagepub.com
The evolution of the subdiscipline of developmental immunotoxicology (DIT) as it exists today
has been shaped by significant regulatory pressures as well as key scientific advances. …