Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent

…, KR Patel, AM Schinas, VA Brown, MP Ducharme… - … Biomarkers & Prevention, 2007 - AACR
The red grape constituent resveratrol possesses cancer chemopreventive properties in
rodents. The hypothesis was tested that, in healthy humans, po administration of resveratrol is …

Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model

…, A Gritsas, J Zhang, JP Moreau, MP Ducharme - Journal of pharmacology …, 2002 - ASPET
Pharmacokinetics of trans-resveratrol in its aglycone (RES AGL ) and glucuronide (RES
GLU ) forms were studied following intravenous (15 mg/kg iv) and oral (50 mg/kg po) …

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

MP Ducharme, LH Warbasse… - Clinical Pharmacology & …, 1995 - Wiley Online Library
Objective To examine the effect of grapefruit juice on the disposition of cyclosporine after
administration of oral and intravenous doses to healthy male subjects. Methods Subjects …

6′, 7′‐Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P‐glycoprotein

…, EG Schuetz, K Yasuda, MP Ducharme… - Clinical …, 1999 - Wiley Online Library
Background 6′,7′‐Dihydroxybergamottin is a furanocoumarin that inhibits CYP3A4 and
is found in grapefruit juice and Seville orange juice. Grapefruit juice increases the oral …

Drug-induced alterations in serum creatinine concentrations

EA Hartshorn, MP Ducharme… - Annals of …, 1993 - journals.sagepub.com
OBJECTIVE: To provide a comprehensive review of drug-induced alterations in serum
creatinine concentrations (SCrs). DATA SOURCES: Information was obtained from a MEDLINE …

Vancomycin pharmacokinetics in a patient population: effect of age, gender, and body weight

MP Ducharme, RL Slaughter… - Therapeutic drug …, 1994 - journals.lww.com
The effects of age, gender, and body weight on the pharmacokinetics of vancomycin were
examined using data collected as part of routine therapeutic drug monitoring in patients. One …

Establishing the suitability of model‐integrated evidence to demonstrate bioequivalence for long‐acting injectable and implantable drug products: summary of …

…, A Kohojkar, AC Hooker, MP Ducharme… - CPT …, 2023 - Wiley Online Library
… Murray Ducharme presented the experience that generic drug industries have had so far
with the FDA in using MIE for LAI products. Two main MIE approaches were contrasted. The …

Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans

…, GJ Merritt, M Vranderick, MP Ducharme - Clinical …, 2006 - Wiley Online Library
… , Sherman Oaks, Calif) were bought from a single retailer at an open fruit and vegetable
market, and juice was obtained by use of a conventional home juice extractor (Braun MP 80, …

The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein

MP Di Marco, DJ Edwards, IW Wainer, MP Ducharme - Life sciences, 2002 - Elsevier
The objective of this study was to determine the effects of grapefruit juice and seville orange
juice on dextromethorphan (DM) pharmacokinetics. Eleven healthy volunteers were studied …

Liposomal tobramycin against pulmonary infections of Pseudomonas aeruginosa: a pharmacokinetic and efficacy study following single and multiple intratracheal …

…, JL Brazier, J Lavigne, MP Ducharme - Journal of …, 2003 - academic.oup.com
Objective: To determine the pharmacokinetics and efficacy of tobramycin against pulmonary
infections of Pseudomonas aeruginosa in rats after intratracheal administration of …