Background Case fatality ratios in children with tuberculosis are poorly understood—particularly
those among children with HIV and children not receiving tuberculosis treatment. We …

Numerous studies have reported that individuals can simultaneously harbor multiple distinct
strains of Mycobacterium tuberculosis . To date, there has been limited discussion of the …

… 150 mM NaCl, 10 mM sodium phosphate pH 7.0 followed by hydroxylapatite chromatography
in 10 mM sodium phosphate pH 7.0, with elution through a linear gradient from 10–20 mM …

S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from
the National Cancer Institute chemical libraries by using structure-based virtual screening …

… The intrinsic ATPase activity of the nonphosphorylated enzyme was inhibited by SB203580
with aK m of 9.6 mm. Kinetic studies of active, phosphorylated yeast-expressed p38 kinase …

Rapamycin is a macrolide antifungal agent that exhibits potent immunosuppressive properties.
In Saccharomyces cerevisiae, rapamycin sensitivity is mediated by a specific cytoplasmic …

Uridine 5′-diphosphoglucose (UDP-glucose) has a well established biochemical role as a
glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is less well known that UDP…

TRAIL is a member of the tumor necrosis factor (TNF) family of cytokines which induces
apoptotic cell death in a variety of tumor cell lines. It mediates its apoptotic effects through one of …

… MM McLaughlin has served on an advisory board for BioCryst Pharmaceuticals. MG Ison
has received research support, paid to Northwestern University, from Anolinx, BioCryst, …

… The beads were washed twice with lysis buffer and twice with kinase buffer (25 mM Hepes,
pH 7.4, 25 mM MgCl 2 , 25 mM β-glycerophosphate, 100 μM sodium orthovanadate, 2 mM …