User profiles for M. L. Dubocovich
Margarita L Dubocovich, PhD, FACNP, FASPETSUNY Distinguished Professor, Jacobs School of Medicine, University at Buffalo (SUNY) Verified email at buffalo.edu Cited by 20129 |
Functional MT1 and MT2 melatonin receptors in mammals
ML Dubocovich, M Markowska - Endocrine, 2005 - Springer
Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of
physiological processes in mammals. This review describes well-defined functional responses …
physiological processes in mammals. This review describes well-defined functional responses …
Melatonin receptors: are there multiple subtypes?
ML Dubocovich - Trends in pharmacological sciences, 1995 - cell.com
… In summary, ML~ and ML 2 melatonin binding sites show different pharmacological profiles
for both agonists and antagonists, strongly suggesting the presence of two distinct subtypes. …
for both agonists and antagonists, strongly suggesting the presence of two distinct subtypes. …
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors
ML Dubocovich, P Delagrange, DN Krause… - Pharmacological …, 2010 - ASPET
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …
Melatonin is a potent modulator of dopamine release in the retina
ML Dubocovich - Nature, 1983 - nature.com
Melatonin, a hormone originally discovered in the pineal gland 1 , has also been found in the
retina of several vertebrate species 2–5 . The enzyme system for melatonin synthesis also …
retina of several vertebrate species 2–5 . The enzyme system for melatonin synthesis also …
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective
…, M Popovska-Gorevski, ML Dubocovich - Annual review of …, 2016 - annualreviews.org
Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal gland
and locally in the retina following a circadian rhythm, with low levels during the day and …
and locally in the retina following a circadian rhythm, with low levels during the day and …
[PDF][PDF] Molecular pharmacology, regulation and function of mammalian melatonin receptors
ML Dubocovich, MA Rivera-Bermudez, MJ Gerdin… - Front …, 2003 - article.imrpress.com
… Dubocovich ML: Melatonin is a potent modulator of dopamine release in the retina. Nature …
Popova JS and ML Dubocovich: Melatonin receptor-mediated stimulation of phosphoinositide …
Popova JS and ML Dubocovich: Melatonin receptor-mediated stimulation of phosphoinositide …
Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats
…, LA Sauer, MA Rivera-Bermudez, ML Dubocovich… - Cancer research, 2005 - AACR
The increased breast cancer risk in female night shift workers has been postulated to result
from the suppression of pineal melatonin production by exposure to light at night. Exposure …
from the suppression of pineal melatonin production by exposure to light at night. Exposure …
Selective MT2 melatonin receptor antagonists block melatonin‐mediated phase advances of circadian rhythms
ML Dubocovich, K Yun, WM Al‐Ghoul… - The FASEB …, 1998 - Wiley Online Library
… serum albumin) in a total reaction volume of 260 ml and incubated at 25C for 1.5 h. Reactions
were … Each filter was washed twice with 5 ml of ice-cold TrisMg buffer. Radioactivity was …
were … Each filter was washed twice with 5 ml of ice-cold TrisMg buffer. Radioactivity was …
Melatonin receptors: role on sleep and circadian rhythm regulation
ML Dubocovich - Sleep medicine, 2007 - Elsevier
The circadian release of the hormone melatonin is regulated by the suprachiasmatic nucleus
(SCN), which feeds back into the nucleus to modulate sleep and circadian phase through …
(SCN), which feeds back into the nucleus to modulate sleep and circadian phase through …
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the …
ML Dubocovich, MI Masana, S Iacob… - … Schmiedeberg's archives of …, 1997 - Springer
… Each filter was washed twice with 5 ml of ice cold Tris-HCl … Retina tissue was superfused
at 1 ml/min with Krebs solution (… in each chamber was solubilized in 0.5 ml of TS-1 (Research …
at 1 ml/min with Krebs solution (… in each chamber was solubilized in 0.5 ml of TS-1 (Research …