User profiles for M. J. Gunthorpe

Martin Gunthorpe

Verified email at alterionconsulting.com
Cited by 10666

The diversity in the vanilloid (TRPV) receptor family of ion channels

MJ Gunthorpe, CD Benham, A Randall… - Trends in pharmacological …, 2002 - cell.com
Following cloning of the vanilloid receptor 1 (VR1) at least four other related proteins have
been identified. Together, these form a distinct subgroup of the transient receptor potential (…

Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential

L Mony, JNC Kew, MJ Gunthorpe… - British journal of …, 2009 - Wiley Online Library
N‐methyl‐D‐aspartate receptors (NMDARs) are ion channels gated by glutamate, the major
excitatory neurotransmitter in the mammalian central nervous system (CNS). They are …

The mechanism of action of retigabine (ezogabine), a first‐in‐class K+ channel opener for the treatment of epilepsy

MJ Gunthorpe, CH Large, R Sankar - Epilepsia, 2012 - Wiley Online Library
The pharmacologic profile of retigabine [RTG (international nonproprietary name); ezogabine,
EZG (US adopted name)], is different from all currently approved antiepileptic drugs (AEDs…

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

JB Davis, J Gray, MJ Gunthorpe, JP Hatcher, PT Davey… - Nature, 2000 - nature.com
The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel expressed
predominantly by sensory neurons. VR1 responds to noxious stimuli including capsaicin, the …

The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

D Smart, MJ Gunthorpe, JC Jerman… - British journal of …, 2000 - Wiley Online Library
The endogenous cannabinoid anandamide was identified as an agonist for the recombinant
human VR1 (hVR1) by screening a large array of bioactive substances using a FLIPR‐…

TRPV3 is a temperature-sensitive vanilloid receptor-like protein

GD Smith, MJ Gunthorpe, RE Kelsell, PD Hayes… - Nature, 2002 - nature.com
Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation
channel that is expressed by capsaicin-sensitive sensory afferents and is activated by …

Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1

M Trevisani, D Smart, MJ Gunthorpe, M Tognetto… - Nature …, 2002 - nature.com
The vanilloid receptor-1 (VR1) is a heat-gated ion channel that is responsible for the burning
sensation elicited by capsaicin. A similar sensation is reported by patients with esophagitis …

[HTML][HTML] Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)

…, A Randall, MJ Gunthorpe - British journal of …, 2005 - ncbi.nlm.nih.gov
… The degree of acid-induced augmentation was similar for piperine 230±20% (n=11) and
capsaicin 284±32% (n=8; P>0.05, unpaired Student's t-test; Figure 4c) and was similar to the …

The voltage-gated sodium channel Nav1. 9 is an effector of peripheral inflammatory pain hypersensitivity

…, V Morisset, D Grose, MJ Gunthorpe… - Journal of …, 2006 - Soc Neuroscience
We used a mouse with deletion of exons 4, 5, and 6 of the SCN11A (sodium channel,
voltage-gated, type XI, α) gene that encodes the voltage-gated sodium channel Na v 1.9 to assess …

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

P Hayes, HJ Meadows, MJ Gunthorpe, MH Harries… - Pain, 2000 - journals.lww.com
Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel,
termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a …