User profiles for M. F. Eckenhoff

Maryellen Fazen Eckenhoff

University of Pennsylvania Perelman School of Medicine
Verified email at uphs.upenn.edu
Cited by 5331

Perioperative neurocognitive disorder: state of the preclinical science

…, N Terrando, BA Orser, MF Eckenhoff - …, 2020 - pubs.asahq.org
The purpose of this article is to provide a succinct summary of the different experimental
approaches that have been used in preclinical postoperative cognitive dysfunction research, …

Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex

P Rakic, JP Bourgeois, MF Eckenhoff, N Zecevic… - Science, 1986 - science.org
Synapses develop concurrently and at identical rates in different layers of the visual,
somatosensory, motor, and prefrontal areas of the primate cerebral cortex. This isochronic course of …

Inhaled anesthetic enhancement of amyloid-β oligomerization and cytotoxicity

…, W Wei, R Pidikiti, JM Keller, MF Eckenhoff - The Journal of the …, 2004 - pubs.asahq.org
Background The majority of surgical patients receive inhaled anesthetics, principally small
haloalkanes and haloethers. Long-term cognitive problems occur in the elderly subsequent to …

Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics

…, S Lin, Y Li, JM Keller, RG Eckenhoff, MF Eckenhoff - Neurobiology of …, 2008 - Elsevier
Inhaled anesthetics have been shown to increase the aggregation of amyloid beta in vitro
through the stabilization of intermediate toxic oligomers, which are thought to contribute to …

Anesthesia and the old brain

J Tang, MF Eckenhoff, RG Eckenhoff - Anesthesia & Analgesia, 2010 - journals.lww.com
The perioperative period may have long-term consequences on cognitive function in the
elderly patient. In this special article, we summarize the rationale and evidence that the …

Human Alzheimer and inflammation biomarkers after anesthesia and surgery

…, LM Shaw, MF Eckenhoff, RG Eckenhoff - The Journal of the …, 2011 - pubs.asahq.org
Background The prevalence of postoperative cognitive disturbance, coupled with growing
in vitro, cell, and animal evidence suggesting anesthetic effects on neurodegeneration, calls …

Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey

MF Eckenhoff, P Rakic - Journal of Neuroscience, 1988 - Soc Neuroscience
The nature of proliferative cells in the subgranular zone (SGZ) of the hippocampal region
and the fate of their progeny was analyzed by 3H- thymidine (3H-TdR) autoradiography …

Radial organization of the hippocampal dentate gyrus: a Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey

MF Eckenhoff, P Rakic - Journal of comparative neurology, 1984 - Wiley Online Library
… A preliminary electron microscopic study indicates that, indeed, the late-generated cells of
the subgranular zone appear to be of the glial cell lineage (Eckenhoff and Rakic, '83). This …

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

…, Z Wu, DJ Joseph, Q Meng, Y Peng, MF Eckenhoff… - Neuroscience …, 2012 - Elsevier
Disruption of intracellular calcium homeostasis via abnormal and excessive activation of
ryanodine receptors plays an important role in the neuropathology of Alzheimer's disease. We …

Consensus statement: first international workshop on anesthetics and Alzheimer's disease

…, DJ Culley, MF Eckenhoff, RG Eckenhoff… - Anesthesia & …, 2009 - journals.lww.com
IMPLICATIONS This article is a consensus view on the possible link between Alzheimer’s
disease and anesthesia and the steps required to test this more definitively. From the* …