Despite high sequence similarity between NOP (nociceptin/orphanin FQ opioid peptide) and
opioid receptors, marked differences in endogenous ligand selectivity, signal transduction, …

Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …

Although mu opioid (MOP) receptor agonists are the most commonly used analgesics for the
treatment of moderate to severe pain in the clinic, the side effects of MOP agonists such as …

Resveratrol is a natural polyphenol and possesses many biological functions such as anti-inflammatory
activity and protection against atherosclerosis and myocardial infraction. …

… Each tissue block (and thus, each slide) contained both wild-type and knockout tissues to
account for any variability in staining between slides, and to control for the specificity of …

Pruritus (itch sensation) is a significant clinical problem. The aim of this study was to elucidate
the roles of opioid receptor types and the site of action in opioid-induced itch in monkeys. …

… pain in wild-type (WT) mice and knockout (KO) mice lacking either the ligand (Il23 … nociceptors
for mechanical pain, we generated Era conditional KO (cKO) mice by crossing Era-floxed …

Cocaine is recognized as the most reinforcing of all drugs of abuse. There is no anticocaine
medication available. The disastrous medical and social consequences of cocaine addiction …

OBJECTIVE This study addresses the strength of association for the bidirectional relationship
between type 2 diabetes and depression. RESEARCH DESIGN AND METHODS We used …

In this paper, the potential-based skeletonization approach for 2D medial axis transform (MAT),
which identifies object skeleton as potential valleys using a Newtonian potential model in …