User profiles for M. B. Thygesen

Mikkel Boas Thygesen

Department of Chemistry, University of Copenhagen
Verified email at chem.ku.dk
Cited by 3333

Solid-phase chemical tools for glycobiology

K Larsen, MB Thygesen, F Guillaumie, WGT Willats… - Carbohydrate …, 2006 - Elsevier
Techniques involving solid supports have played crucial roles in the development of genomics,
proteomics, and in molecular biology in general. Simularly, methods for immobilization or …

Chemoselective reactions for the synthesis of glycoconjugates from unprotected carbohydrates

…, KJ Jensen, MB Thygesen - …, 2017 - Wiley Online Library
Glycobiology is the comprehensive biological investigation of carbohydrates. The study of the
role and function of complex carbohydrates often requires the attachment of carbohydrates …

Receptor-mediated exopolysaccharide perception controls bacterial infection

…, K Gysel, A Muszyński, RW Carlson, MB Thygesen… - Nature, 2015 - nature.com
Surface polysaccharides are important for bacterial interactions with multicellular organisms,
and some are virulence factors in pathogens. In the legume–rhizobium symbiosis, bacterial …

Legume receptors perceive the rhizobial lipochitin oligosaccharide signal molecules by direct binding

…, S Thirup, CW Ronson, MB Thygesen… - Proceedings of the …, 2012 - National Acad Sciences
Lipochitin oligosaccharides called Nod factors function as primary rhizobial signal molecules
triggering legumes to develop new plant organs: root nodules that host the bacteria as …

Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl) carbamide (2R, 3R) …

…, TR Ott, ES Burstein, AK Uldam, MB Thygesen… - … of Pharmacology and …, 2006 - ASPET
The in vitro and in vivo pharmacological properties of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide
(2R,3R)-…

[HTML][HTML] A combination of chitooligosaccharide and lipochitooligosaccharide recognition promotes arbuscular mycorrhizal associations in Medicago truncatula

…, S Fort, A Gavrin, K Gysel, MB Thygesen… - Nature …, 2019 - nature.com
Plants associate with beneficial arbuscular mycorrhizal fungi facilitating nutrient acquisition.
Arbuscular mycorrhizal fungi produce chitooligosaccharides (COs) and lipo-…

Impact of Chain Length on Antibacterial Activity and Hemocompatibility of Quaternary N-Alkyl and N,N-Dialkyl Chitosan Derivatives

…, KK Sørensen, MB Thygesen… - …, 2015 - ACS Publications
A highly efficient method for chemical modification of chitosan biopolymers by reductive
amination to yield N,N-dialkyl chitosan derivatives was developed. The use of 3,6-O-di-tert-…

Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity

…, N de Jong, M Vinther, M Kamble, MB Thygesen… - Science, 2020 - science.org
Plants evolved lysine motif (LysM) receptors to recognize and parse microbial elicitors and
drive intracellular signaling to limit or facilitate microbial colonization. We investigated how …

Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers

…, KJ Jensen, M Másson, MB Thygesen - Chemical …, 2015 - pubs.rsc.org
Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is
a strategy for abolishing the hemolytic propensity, and at the same time increasing the …

Switching of bacterial adhesion to a glycosylated surface by reversible reorientation of the carbohydrate ligand

…, I Stamer, MB Thygesen… - Angewandte Chemie …, 2014 - Wiley Online Library
The surface recognition in many biological systems is guided by the interaction of
carbohydrate‐specific proteins (lectins) with carbohydrate epitopes (ligands) located within the …