The adducin heterodimer is a protein affecting the assembly of the actin-based cytoskeleton.
Point mutations in rat adducin alpha (F316Y) and beta (Q529R) subunits are involved in a …

The Milan hypertensive strain of rats (MHS) develops a genetic form of renal hypertension
that, when compared to its normotensive control (MNS), shows renal dysfunction similar to that …

The inhibition of the long-term pressor effect of ouabain may be useful for the therapy of
essential hypertension. Here, for the first time, a selective inhibitor of the ouabain pressor effect …

… The aa 250–536 L would become flexible and free to interact with other cellular proteins and
membranes.Notably, the L sequence contains a number of aromatic and basic amino acids, …

Computational chemistry has come of age in drug discovery. Indeed, most pharmaceutical
development programs rely on computer-based data and results at some point. Herein, we …

The significance of the erythrocyte abnormalities described in rats and humans with
spontaneous hypertension is far from clear. This study, in two highly inbred strains of rats, was …

Herein we examine the determinants of the allosteric inhibition of the mitochondrial chaperone
TRAP1 by a small molecule ligand. The knowledge generated is harnessed into the …

A genetic alteration in the adducin genes is associated with hypertension and up-regulation
of the expression of renal Na,K-ATPase in Milan-hypertensive (MHS) rats, in which …

Genetic variation in α-adducin cytoskeletal protein is implicated in the polymerization and
bundling of actin and alteration of the Na/K pump, resulting in abnormal renal sodium transport …

… In particular, both adducin polymorphism [40] and the ouabain exposure [Torielli L., personal
… , show a normalisation of the Na-K pump endocytosis [Torielli L, personal communication]. …