The use of antibody-drug conjugates (ADCs) as a therapeutic platform to treat cancer has
recently gained substantial momentum. This therapeutic modality has the potential to increase …

Using an expanded genetic code, antibodies with site-specifically incorporated nonnative
amino acids were produced in stable cell lines derived from a CHO cell line with titers over 1 g/…

… Serum sex hormone binding gobulin (SHBG) levels were measured by an immunofluorometric
assay that has a sensitivity of 6.25 nmol/L. Body composition was assessed at baseline …

Bispecific antibodies offer a promising approach for the treatment of cancer but can be
challenging to engineer and manufacture. Here we report the development of PF-06671008, an …

… In chickens, single functional v-genes exist for both the L and H chains, containing
unique V L –J L , V H –J H , and D segments (8, 20, 21). To use a restricted v-gene germline …

Advances in recombinant antibody technology and protein engineering have provided the
opportunity to reduce antibodies to their smallest binding domain components and have …

The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the
shark immune system that exist as heavy chain-only homodimers and bind antigens by their …

A large body of data exists demonstrating that neonatal Fc receptor (FcRn) binding of an
IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG. We have …

… A second family of improved clones had a different motif at positions 99–100a composed
of L/V–D–S/G or L–V–G/S sequences. The T99K/R/L and T100V/D mutations represent …

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease leading to
motor neuron cell death, but recent studies suggest that non-neuronal cells may contribute to …