[HTML][HTML] Phase Ib study of lenvatinib plus pembrolizumab in patients with unresectable hepatocellular carcinoma
…, K Saito, AB Siegel, L Dubrovsky… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
PURPOSE The immunomodulatory effect of lenvatinib (a multikinase inhibitor) on tumor
microenvironments may contribute to antitumor activity when combined with programmed death …
microenvironments may contribute to antitumor activity when combined with programmed death …
LBA34 Primary results from the phase III LEAP-002 study: Lenvatinib plus pembrolizumab versus lenvatinib as first-line (1L) therapy for advanced hepatocellular …
…, H Kumada, A Wang, K Mody, L Dubrovsky… - Annals of …, 2022 - annalsofoncology.org
Background The global, randomized, double-blind, Ph3 LEAP-002 study (NCT03713593)
evaluated the efficacy and safety of lenvatinib+ pembrolizumab (lenva+ pembro) vs lenvatinib (…
evaluated the efficacy and safety of lenvatinib+ pembrolizumab (lenva+ pembro) vs lenvatinib (…
[HTML][HTML] Human immunodeficiency virus impairs reverse cholesterol transport from macrophages
…, H Rose, MP Morrow, T Pushkarsky, L Dubrovsky… - PLoS …, 2006 - journals.plos.org
Several steps of HIV-1 replication critically depend on cholesterol. HIV infection is associated
with profound changes in lipid and lipoprotein metabolism and an increased risk of …
with profound changes in lipid and lipoprotein metabolism and an increased risk of …
CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A
T Pushkarsky, G Zybarth, L Dubrovsky… - Proceedings of the …, 2001 - National Acad Sciences
Cyclophilin A (CyPA) is specifically incorporated into the virions of HIV-1 and has been shown
to enhance significantly an early step of cellular HIV-1 infection. Our preliminary studies …
to enhance significantly an early step of cellular HIV-1 infection. Our preliminary studies …
Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex
OK Haffar, S Popov, L Dubrovsky, I Agostini… - Journal of molecular …, 2000 - Elsevier
Replication of HIV-1 in non-dividing and slowly proliferating cell populations depends on
active import of the viral pre-integration complex (PIC) into the cell nucleus. While it is …
active import of the viral pre-integration complex (PIC) into the cell nucleus. While it is …
Therapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1
…, N Veomett, L Dubrovsky… - Nature …, 2015 - nature.com
Intracellular tumor antigens presented on the cell surface in the context of human leukocyte
antigen (HLA) molecules have been targeted by T cell–based therapies, but there has been …
antigen (HLA) molecules have been targeted by T cell–based therapies, but there has been …
Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease.
…, HS Nottet, H Schmidtmayerova, L Dubrovsky… - The Journal of …, 1995 - rupress.org
… Since NMA competes with L-arginine for both the transporter and for the NOS enzyme, the
observed variation between the murine and human cells could be attributed to the differences …
observed variation between the murine and human cells could be attributed to the differences …
Lenvatinib (len) plus pembrolizumab (pembro) for the first-line treatment of patients (pts) with advanced hepatocellular carcinoma (HCC): Phase 3 LEAP-002 study.
…, T Meyer, S Qin, CE Dutcus, E Chen, L Dubrovsky… - 2019 - ascopubs.org
TPS4152 Background: Len, an inhibitor of VEGF receptors 1-3, FGF receptors 1-4, PDGF
receptor α, RET, and KIT, is approved for first-line treatment of unresectable HCC (uHCC) …
receptor α, RET, and KIT, is approved for first-line treatment of unresectable HCC (uHCC) …
Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain …
…, T Raabe, CR Flanagan, L Dubrovsky… - Proceedings of the …, 1996 - National Acad Sciences
Two chemokine (chemoattractant cytokines) beta peptides, macrophage inflammatory
proteins 1 alpha and 1 beta (MIP-1 alpha and MIP-1 beta), were induced in human monocyte …
proteins 1 alpha and 1 beta (MIP-1 alpha and MIP-1 beta), were induced in human monocyte …
Lenvatinib plus pembrolizumab versus lenvatinib plus placebo for advanced hepatocellular carcinoma (LEAP-002): a randomised, double-blind, phase 3 trial
…, A Wang, K Mody, C Dutcus, L Dubrovsky… - The Lancet …, 2023 - thelancet.com
Background Systemic therapies have improved the management of hepatocellular carcinoma,
but there is still a need to further enhance overall survival in first-line advanced stages. …
but there is still a need to further enhance overall survival in first-line advanced stages. …