Screening a diverse, combinatorial library of ca. 5000 synthetic dimer and trimer N-(substituted)
glycine “peptoids” yielded novel, high-affinity ligands for 7-transmembrane G-protein-…

We characterize the in vitro and in vivo pharmacology of CHIR 2279, an N-substituted
glycine peptoid previously identified from a combinatorial library as a novel ligand to alpha 1-…

The Mitsunobu reaction of N-Boc-L-Tyrosine methyl ester with hydroxymethyl polystyrene
resin proceeds in practically quantitative yield in the presence of a tertiary amine. Coupling …

Synthesis and screening of combinatorial librariesfor pharmaceutical lead discovery is a
rapidlyexpanding field. Oligo-N-substituted glycines (NSGs)were one of the earliest sources of …

A novel linkage for the solid-phase synthesis of hydroxamic acids is described. The linkage
is stable to all reagents commonly used in Fmoc peptide synthsis. Cleavage is induced by …

Two new methods for the benzylation of thiols are described: a) direct S—alkylation with
para-substituted benzylic cations; and b) reductive S—alkylations of 2-aminothiols. Both …

A series of cyclic penta-, hexa- and heptapeptides was synthesized using a novel cyclization
strategy. After attachment of the first amino acid to the solid support with a thioester-linkage, …

A simple, versatile method for the synthesis of Peptide Nucleic Acids (PNA) from readily
available building blocks has been developed. The approach is based on submonomer solid …

WE are at present at a climax of national exultation over the most magnificent military triumph
in our long record of victory. We are the happiest and proudest of empires. Such pageantry …

… ls a countable abelian group whose isomorphism class is of degree d. … satisfying condition
(2) of Theorem 2.1 are discussed in Richter [3]. These are the theories of partially ordered sets…