Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase
…, BF Kilpatrick, BL Parnas, LJ Askonas… - Journal of medicinal …, 2000 - ACS Publications
Leukotriene B 4 (LTB 4 ) is a pro-inflammatory mediator that has been implicated in the
pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. …
pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. …
Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid
…, JM Miyashiro, SS Yu, LJ Askonas… - Journal of medicinal …, 2002 - ACS Publications
Leukotriene B 4 (LTB 4 ) is a potent, proinflammatory mediator involved in the pathogenesis
of a number of diseases including inflammatory bowel disease, psoriasis, rheumatoid …
of a number of diseases including inflammatory bowel disease, psoriasis, rheumatoid …
The kinetic mechanism catalysed by homogeneous rat liver 3α-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non …
LJ Askonas, JW Ricigliano, TM Penning - Biochemical Journal, 1991 - portlandpress.com
Rat liver 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) (EC 1.1.1.50) is an NAD(P)(+)-dependent
oxidoreductase that is potently inhibited at its active site by non-steroidal anti-…
oxidoreductase that is potently inhibited at its active site by non-steroidal anti-…
Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase
TD Penning, LJ Askonas, SW Djuric, RA Haack… - Bioorganic & medicinal …, 1995 - Elsevier
The hydroxamic acid-containing peptide kelatorphan, a known inhibitor of enkephalin-degrading
enzymes, is a potent, non-competitive inhibitor of leukotriene A 4 (LTA 4 ) hydrolase. …
enzymes, is a potent, non-competitive inhibitor of leukotriene A 4 (LTA 4 ) hydrolase. …
Pharmacological Characterization of SC-57461A (3-[Methyl [3-[4-(phenylmethyl) phenoxy] propyl] amino] propanoic Acid HCl), a Potent and Selective Inhibitor of …
LJ Askonas, JF Kachur, D Villani-Price… - … of Pharmacology and …, 2002 - ASPET
Leukotriene (LT) B 4 is an inflammatory mediator that has been implicated in the pathogenesis
of various diseases, including inflammatory bowel disease and psoriasis. As the rate-…
of various diseases, including inflammatory bowel disease and psoriasis. As the rate-…
Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase
…, JM Miyashiro, MA Russell, LJ Askonas… - Bioorganic & medicinal …, 2003 - Elsevier
The synthesis and biological evaluation of a series of heterocyclic analogues of the
previously reported LTA 4 hydrolase inhibitor 1b are described. Imidazopyridine and purine …
previously reported LTA 4 hydrolase inhibitor 1b are described. Imidazopyridine and purine …
Pharmacological Characterization of SC-57461A (3-[Methyl [3-[4-(phenylmethyl) phenoxy] propyl] amino] propanoic Acid HCl), a Potent and Selective Inhibitor of …
JF Kachur, LJ Askonas, D Villani-Price… - … of Pharmacology and …, 2002 - ASPET
Leukotriene (LT) A 4 hydrolase is a dual function enzyme that is essential for the conversion
of LTA 4 to LTB 4 and also possesses an aminopeptidase activity. SC-57461A (3-[methyl[3-[…
of LTA 4 to LTB 4 and also possesses an aminopeptidase activity. SC-57461A (3-[methyl[3-[…
Rat liver 3 alpha-hydroxysteroid dehydrogenase.
TM Penning, TE Smithgall, LJ Askonas, RB Sharp - Steroids, 1986 - europepmc.org
3 alpha-HSD appears to be a multifunctional enzyme. In addition to its traditional role of
catalyzing early steps in androgen metabolism, it will also oxidoreduce prostaglandins and …
catalyzing early steps in androgen metabolism, it will also oxidoreduce prostaglandins and …
9-(5', 6'-Dideoxy-. beta.-D-ribohex-5'-ynofuranosyl) adenine, a novel irreversible inhibitor of S-adenosylhomocysteine hydrolase
RJ Parry, A Muscate, LJ Askonas - Biochemistry, 1991 - ACS Publications
… of the hydrolysis have been shown to proceed with syn geometry (Parry & Askonas,1985).
This stereochemistry is in accord with the generalization that enzyme-catalyzed /3-de- …
This stereochemistry is in accord with the generalization that enzyme-catalyzed /3-de- …
High-level expression and purification of human leukotriene A4 hydrolase from insect cells infected with a baculovirus vector
JK Gierse, VA Luckow, LJ Askonas, KL Duffin… - Protein expression and …, 1993 - Elsevier
Leukotrienes constitute a group of bioactive compounds derived from arachidonic acid
which play important roles in immediate hypersensitivity and inflammation. Leukotriene A 4 …
which play important roles in immediate hypersensitivity and inflammation. Leukotriene A 4 …