Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe
a luciferase knockin mouse (p16 LUC ), which faithfully reports expression of p16 INK4a , a …

NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in melanoma,
such alterations are nearly exclusive to codon 61. Here, we compared the melanoma …

B cell lymphoma and melanoma harbor recurrent mutations in the gene encoding the EZH2
histone methyltransferase (EZH2), but the carcinogenic role of these mutations is unclear. …

Tumor-initiating cells (TICs) are a sub-population of cells that exhibit a robust ability to self-renew
and contribute to the formation of primary tumors, the relapse of previously treated …

… The CO 2 exchange between the forest and the atmosphere (NEE) was measured by the
eddy-covariance technique as detailed in Clark et al. (2010). Gross primary productivity (GPP) …

Caffeine and its derivatives have been used, alone and in combination with other phytochemicals,
as weight‐loss supplements. Caffeine affects several physiological and behavioural …

Voltage-gated Ca 2+ channels in vertebrates comprise at least seven molecular subtypes,
each of which produces a current with distinct kinetics and pharmacology. Although several …

PREMISE Due to climate change, more frequent and intense periodic droughts are predicted
to increasingly pose major challenges to the persistence of plant populations. When a …

We previously proposed three hypotheses relating the mechanism of antimicrobial and
cytolytic peptides in model membranes to the Gibbs free energies of binding and insertion into …

The development of α 1a -adrenergic receptor (AR) subtype-selective antagonists is likely to
result in uroselective agents that effectively treat benign prostatic hyperplasia (BPH) …