Serotonin is a major component of the inflammatory chemical milieu and contributes to the
pain of tissue injury via an action on multiple receptor subtypes. Here we studied mice after …

A variety of second messenger systems have been implicated in the intracellular mechanisms
of tolerance development to the analgesic actions of morphine, a mu opioid, and clonidine…

Increases in neuronal activity in response to tissue or nerve injury can lead to prolonged
functional changes in the spinal cord resulting in an enhancement/sensitization of nociceptive …

Prodynorphin-derived peptides elicit various pathological effects including neurological
dysfunction and cell death. These actions are reduced by N-methyl-d-aspartate receptor (…

The bradykinin B 1 receptor plays a critical role in chronic pain and inflammation, although
efforts to demonstrate efficacy of receptor antagonists have been hampered by species-…

Increases in neuronal activity in response to tissue or nerve injury can lead to prolonged
functional changes in the spinal cord resulting in an enhancement/sensitization of nociceptive …

Serotonin is a major component of the inflammatory chemical milieu and contributes to the
pain of tissue injury via an action on multiple receptor subtypes. Here we studied mice after …

Tissue injury not only activates primary afferent nociceptors to produce acute pain but it also
initiates changes in the properties of nociceptors and spinal cord nociresponsive neurons. …

A variety of second messenger systems have been implicated in the intracellular mechanisms
of tolerance development to the analgesic actions of morphine, a mu opioid, and clonidine…

Injury-evoked persistent pain is mediated by changes in nociceptive processing in both the
peripheral and central nervous systems. Although many mechanisms have been implicated …