Progressive neuronal cell loss in a small subset of brainstem and mesencephalic nuclei and
widespread aggregation of the α-synuclein protein in the form of Lewy bodies and Lewy …

Parkinson's disease biomarkers are needed to increase diagnostic accuracy, to objectively
monitor disease progression and to assess therapeutic efficacy as well as target engagement …

Postmortem AD brains exhibit dendritic spine loss in the hippocampus. To determine whether
this pathology may be associated with amyloid burden, the present study used the Golgi …

The convergence of human molecular genetics and Lewy pathology of Parkinson’s disease
(PD) have led to a robust, clinical-stage pipeline of alpha-synuclein (α-syn)-targeted …

Several studies indicate a role for the serotonin 2 subfamily (5-HT 2A , 5-HT 2B , 5-HT 2C ) in
mediation of fear and anxiety responses. The current study began to examine the effects of …

The Drosophila learning mutant, rutabaga, is deficient in the calmodulin-sensitive adenylate
cyclase, and studies of associative learning in Aplysia have implicated this enzyme in …

Human genetic variants predicted to cause loss-of-function of protein-coding genes (pLoF
variants) provide natural in vivo models of human gene inactivation and can be valuable …

A previous study by us suggests the utility of cerebrospinal fluid (CSF) and plasma Aβ as
biomarkers of β- or γ-secretase inhibition. The present study characterized further Aβ …

Using magnetic resonance diffusion tensor imaging (DTI), the present study investigates
changes in both gray and white matter in the APPsw transgenic mouse (Tg2576), a model of β-…

In the rat, administration of the psychoactive analog of amphetamine 3,4-methylenedioxy-methamphetamine
(MDMA), causes selective, pronouced decreases in markers of central …