The anaphylatoxin C3a is a potent chemotactic peptide and inflammatory mediator released
during complement activation which binds to and activates a G-protein-coupled receptor. …

Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38)
kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR …

Plants have distinct RNA polymerase complexes (Pol IV and Pol V) with largely unknown
roles in maintaining small RNA–associated gene silencing. Curiously, the eudicot Arabidopsis …

Introduction. The vitronectin receptor, also known as Rvβ3, is a member of the integrin family
of heterodimeric transmembrane glycoprotein complexes that function in cellular adhesion …

Cathepsin K is a cysteine protease that plays an essential role in osteoclast‐mediated
degradation of the organic matrix of bone. Knockout of the enzyme in mice, as well as lack of …

A novel series of potent and selective hexokinase 2 (HK2) inhibitors, 2,6-disubstituted
glucosamines, has been identified based on HTS hits, exemplified by compound 1. Inhibitor-…

All eukaryotes use three DNA-dependent RNA polymerases (RNAPs) to create cellular RNAs
from DNA templates. Plants have additional RNAPs related to Pol II, but their evolutionary …

Mutations affecting the heritable maintenance of epigenetic states in maize identify multiple
small RNA biogenesis factors including NRPD1, the largest subunit of the presumed maize …

The profound vasoconstriction and mitogenic activity exerted by endothelin-1 (ET-1) and
other closely related isopeptides [endothelin-2 (ET-2) and endothelin-3 (ET-3)] on the …

RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway
contributing to a variety of human pathologies, including immune-mediated inflammatory …