Matrix Metalloproteinase‐1 is the Major Collagenolytic Enzyme Responsible for Collagen Damage in UV‐irradiated Human Skin

M Brennan, H Bhatti, KC Nerusu… - Photochemistry and …, 2003 - Wiley Online Library
Punch biopsies of human skin were obtained 1 day after irradiation with two minimal‐erythema
doses (MED) from either a UVB light source or a Solar Simulator and incubated in organ …

Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in …

RL Warner, N Bhagavathula, KC Nerusu… - … and molecular pathology, 2004 - Elsevier
Recent studies have demonstrated important pro-inflammatory roles for two matrix
metalloproteinases (MMPs)—MMP-3 (stromelysin-1) and MMP-9 (gelatinase B)—in acute lung injury …

Regulation of E‐cadherin and β‐catenin by Ca2+ in colon carcinoma is dependent on calcium‐sensing receptor expression and function

…, AW Hanosh, KC Nerusu… - … journal of cancer, 2007 - Wiley Online Library
An siRNA directed against the extracellular calcium‐sensing receptor (CaSR) was used to
down‐regulate this protein in CBS colon carcinoma cells. In additional studies, we utilized a …

Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury

KC Nerusu, RL Warner, N Bhagavathula… - … and molecular pathology, 2007 - Elsevier
Mice lacking matrix metalloproteinase-3 (MMP-3; stromelysin-1) demonstrated significantly
less injury than their normal counterparts following the formation of IgG-containing immune …

Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen

…, SD Shapiro, N Bhagarvathula, KC Nerusu… - The American journal of …, 2004 - Elsevier
Our laboratory and others have shown an important role of metalloelastase (MMP-12) in the
pathogenesis of acute and chronic lung injury. Because chronic asthma is characterized by …

[HTML][HTML] Rosiglitazone inhibits proliferation, motility, and matrix metalloproteinase production in keratinocytes

N Bhagavathula, KC Nerusu, A Lal, CN Ellis… - Journal of investigative …, 2004 - Elsevier
This study was undertaken to evaluate the effects of thiazolidinediones (TZD) on keratinocyte
proliferation, motility, and matrix metalloproteinase (MMP) production. Rosiglitazone (a …

Amphiregulin and epidermal hyperplasia: amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on severe combined immunodeficient …

N Bhagavathula, KC Nerusu, GJ Fisher, G Liu… - The American journal of …, 2005 - Elsevier
Overexpression of amphiregulin has been shown to induce psoriasiform changes in the
skin of transgenic mice shortly after birth. Therefore, amphiregulin has been suggested as a …

[HTML][HTML] Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma

…, EA Kelley, M Reddy, KC Nerusu… - British journal of …, 2005 - nature.com
In the present study, we demonstrate that Ca 2+-induced growth inhibition and induction of
differentiation in a line of human colon carcinoma cells (CBS) is dependent on mitogen-…

7-chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4, 5-dihydro-1H-benzo [b][1, 4] diazepin-2 (3H)-one (Bz-423), a benzodiazepine, suppresses …

N Bhagavathula, KC Nerusu, A Hanosh… - … of Pharmacology and …, 2008 - ASPET
… Bhagavathula N, Nerusu KC, Reddy M, Ellis CN, Chittiboyina A, Avery M, Pershadsingh
HA, Kurtz TW, and Varani J (2005b) BP-1107 [{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)-phenoxy]-…

A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin

J Varani, N Bhagavathula, KC Nerusu, H Sherzer… - … of Pharmacology and …, 2005 - ASPET
Bz-423 is a new benzodiazepine that has cytotoxic and cytostatic effects against a number
of cell types in culture, and recent studies have shown efficacy in experimental lupus models …