… Stauderman; STIM1, an essential and conserved component of store-operated Ca 2+
channel function . J Cell Biol 9 May 2005; 169 (3): 435–445. doi: https://doi.org/10.1083/jcb.…

As the sole Ca 2+ entry mechanism in a variety of non-excitable cells, store-operated calcium
(SOC) influx is important in Ca 2+ signalling and many other cellular processes 1 , 2 , 3 . A …

Recent studies by our group and others demonstrated a required and conserved role of Stim
in store-operated Ca 2+ influx and Ca 2+ release-activated Ca 2+ (CRAC) channel activity. …

Peripheral nerve injury can lead to a persistent neuropathic pain state in which innocuous
tactile stimulation elicits pain behavior (tactile allodynia). Spinal administration of the …

For efficient development of an immune response, T lymphocytes require long-lasting calcium
influx through calcium release-activated calcium (CRAC) channels and the formation of a …

Mutations in α 1A , the pore-forming subunit of P/Q-type calcium channels, are linked to
several human diseases, including familial hemiplegic migraine (FHM). We introduced the four …

Alzheimer's disease (AD) is characterized pathologically by the abundance of senile
plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase …

Ca 2+ release-activated Ca 2+ (CRAC) channels, located in the plasma membrane, are
opened upon release of Ca 2+ from intracellular stores, permitting Ca 2+ entry and sustained […

Familial hemiplegic migraine, episodic ataxia type 2 (EA2), and spinocerebellar ataxia type
6 are allelic disorders of the CACNA1A gene (coding for the α 1A subunit of P/Q calcium …

Calcium release-activated calcium (CRAC) channels have been the target of drug discovery
for many years. The identification of STIM and Orai proteins as key components of CRAC …