User profiles for K. A. Houck
Keith A HouckUS EPA, Center for Computational Toxicology and Exposure Verified email at epa.gov Cited by 26334 |
The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA
Vascular endothelial growth factor (VEGF) was recently identified as a secreted, direct-acting
mitogen specific for vascular endothelial cells and capable of stimulating angiogenesis in …
mitogen specific for vascular endothelial cells and capable of stimulating angiogenesis in …
[HTML][HTML] Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.
KA Houck, DW Leung, AM Rowland, J Winer… - Journal of Biological …, 1992 - Elsevier
The vascular endothelial growth factor (VEGF) family encompasses four polypeptides that
result from alternative splicing of mRNA. We have previously demonstrated differences in the …
result from alternative splicing of mRNA. We have previously demonstrated differences in the …
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.
The recently identified placenta growth factor (PIGF) is a member of the vascular endothelial
growth factor (VEGF) family of growth factors. PIGF displays a 53% identity with the platelet-…
growth factor (VEGF) family of growth factors. PIGF displays a 53% identity with the platelet-…
The ToxCast program for prioritizing toxicity testing of environmental chemicals
The US Environmental Protection Agency (EPA) is developing methods for utilizing computational
chemistry, high-throughput screening (HTS), and various toxicogenomic technologies …
chemistry, high-throughput screening (HTS), and various toxicogenomic technologies …
The vascular endothelial growth factor family of polypeptides
Vascular endothelial growth factor (VEGF) was identified as a heparin‐binding polypeptide
mitogen with a target cell specificity restricted to vascular endothelial cells. Molecular cloning …
mitogen with a target cell specificity restricted to vascular endothelial cells. Molecular cloning …
In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
Background Chemical toxicity testing is being transformed by advances in biology and
computer modeling, concerns over animal use, and the thousands of environmental chemicals …
computer modeling, concerns over animal use, and the thousands of environmental chemicals …
ToxCast chemical landscape: paving the road to 21st century toxicology
The US Environmental Protection Agency’s (EPA) ToxCast program is testing a large library
of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to …
of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to …
Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment
…, DJ Dix, ME Andersen, KA Houck… - Toxicological …, 2012 - academic.oup.com
High-throughput in vitro toxicity screening can provide an efficient way to identify potential
biological targets for chemicals. However, relying on nominal assay concentrations may …
biological targets for chemicals. However, relying on nominal assay concentrations may …
Zebrafish developmental screening of the ToxCast™ Phase I chemical library
Zebrafish (Danio rerio) is an emerging toxicity screening model for both human health and
ecology. As part of the Computational Toxicology Research Program of the US EPA, the …
ecology. As part of the Computational Toxicology Research Program of the US EPA, the …
Endocrine profiling and prioritization of environmental chemicals using ToxCast data
Background The prioritization of chemicals for toxicity testing is a primary goal of the US
Environmental Protection Agency (EPA) ToxCast™ program. Phase I of ToxCast used a battery …
Environmental Protection Agency (EPA) ToxCast™ program. Phase I of ToxCast used a battery …