5-HT1A receptor agonists: recent developments and controversial issues
J De Vry - Psychopharmacology, 1995 - Springer
During the last decade, serotonin (5-HT) 1A receptors have been a major target for neurobiological
research and drug development. 5-HT 1A receptors have been cloned and a variety …
research and drug development. 5-HT 1A receptors have been cloned and a variety …
Defeat stress in rodents: from behavior to molecules
…, J De Vry, DLA van den Hove, J Prickaerts… - Neuroscience & …, 2015 - Elsevier
Mood and anxiety disorders are prevalent conditions affecting one out of four people during
lifetime. The development of high validity animal models to study these disorders has been a …
lifetime. The development of high validity animal models to study these disorders has been a …
Effects of selected serotonin 5-HT1 and 5-HT2 receptor agonists on feeding behavior: possible mechanisms of action
J De Vry, R Schreiber - Neuroscience & Biobehavioral Reviews, 2000 - Elsevier
Serotonin (5-HT) receptor agonists with high affinity for the different subtypes (ie 5-HT 1A–1F
, 5-HT 2A–2C ) of the 5-HT 1 - and 5-HT 2 receptor families have been shown to affect …
, 5-HT 2A–2C ) of the 5-HT 1 - and 5-HT 2 receptor families have been shown to affect …
(–)-(1R, 2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel μ-opioid receptor agonist/norepinephrine reuptake inhibitor …
…, U Jahnel, TIFH Cremers, E Friderichs, J De Vry - Journal of pharmacology …, 2007 - ASPET
(–)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol
HCl) is a novel μ-opioid receptor (MOR) agonist (K i = 0.1 μM; relative efficacy compared …
HCl) is a novel μ-opioid receptor (MOR) agonist (K i = 0.1 μM; relative efficacy compared …
The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents
FJ van der Staay, K Rutten, L Bärfacker, J DeVry… - …, 2008 - Elsevier
The present study investigated the putative pro-cognitive effects of the novel selective PDE9
inhibitor BAY 73-6691. The effects on basal synaptic transmission and long-term …
inhibitor BAY 73-6691. The effects on basal synaptic transmission and long-term …
Pharmacological characterization of the chronic constriction injury model of neuropathic pain
J De Vry, E Kuhl, P Franken-Kunkel, G Eckel - European journal of …, 2004 - Elsevier
The chronic constriction injury model is a rat model of neuropathic pain based on a unilateral
loose ligation of the sciatic nerve. The aim of the present study was to test its sensitivity to …
loose ligation of the sciatic nerve. The aim of the present study was to test its sensitivity to …
Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist
…, H Beier, W Englberger, S Schunk, J De Vry… - … of Pharmacology and …, 2014 - ASPET
… The antihypersensitive activity of cebranopadol in the spinal nerve ligation model was
partially reversed by pretreatment with the selective NOP receptor antagonist J-113397[1-[(3R,4R)-…
partially reversed by pretreatment with the selective NOP receptor antagonist J-113397[1-[(3R,4R)-…
Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs
J De Vry, U Benz, R Schreiber, J Traber - European journal of …, 1993 - Elsevier
… De Vry, 1990, Neuro-anatomical correlate of the anxiolytic effects of the 5-HT1A receptor
ligands 8… and J. De Vry, 1993b, Neuronal circuits involved in the anxiolytic effects of the 5-HT1A …
ligands 8… and J. De Vry, 1993b, Neuronal circuits involved in the anxiolytic effects of the 5-HT1A …
The novel α7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo [2.2. 2] oct-3-yl]-7-[2-(methoxy) phenyl]-1-benzofuran-2-carboxamide improves working and …
…, J De Vry, C Erb, T Flessner, M Hendrix, J Luithle… - … of Pharmacology and …, 2007 - ASPET
The relative contribution of α4β2, α7 and other nicotinic acetylcholine receptor (nAChR)
subtypes to the memory enhancing versus the addictive effects of nicotine is the subject of …
subtypes to the memory enhancing versus the addictive effects of nicotine is the subject of …
Synergistic interaction between the two mechanisms of action of tapentadol in analgesia
…, TM Tzschentke, R Terlinden, J De Vry… - … of Pharmacology and …, 2011 - ASPET
The novel centrally acting analgesic tapentadol [(−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
hydrochloride] combines two mechanisms of action, μ-opioid receptor (…
hydrochloride] combines two mechanisms of action, μ-opioid receptor (…