Calcitonin gene-related peptide is a potent vasodilator

SD Brain, TJ Williams, JR Tippins, HR Morris… - Nature, 1985 - nature.com
A novel peptide, calcitonin gene-related peptide (CGRP), has been predicted to result from
alternative processing of the primary RNA transcript of the calcitonin gene in the rat 1,2 . …

Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention

MK Sinha, DC Gaze, JR Tippins, PO Collinson… - Circulation, 2003 - Am Heart Assoc
Background— Ischemia modified albumin (IMA; Ischemia Technologies, Inc) blood levels
rise in patients who develop ischemia during percutaneous coronary intervention (PCI). It is …

Isolation and characterization of human calcitonin gene-related peptide

HR Morris, M Panico, T Etienne, J Tippins, SI Girgis… - Nature, 1984 - nature.com
The rat calcitonin gene has recently been shown to encode a novel peptide (rat calcitonin
gene-related peptide, rCGRP) thought to be produced in nervous tissue after tissue-specific …

Potent vasodilator activity of calcitonin gene-related peptide in human skin

SD Brain, JR Tippins, HR Morris, I Maclntyre… - Journal of investigative …, 1986 - Elsevier
We have recently shown that the novel neuropeptide calcitonin gene-related peptide, CGRP,
is a potent vasodilator. In this paper we report a detailed study of the effects of CGRP in …

Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice

…, SJ Heales, ER Werner, JR Tippins… - … , and vascular biology, 2001 - Am Heart Assoc
(6R)-5,6,7,8-Tetrahydro-biopterin (H 4 B) is essential for the catalytic activity of all NO synthases.
The hyperphenylalaninemic mouse mutant (hph-1) displays 90% deficiency of the GTP …

Structure of slow-reacting substance of anaphylaxis from guinea-pig lung

HR Morris, GW Taylor, PJ Piper, JR Tippins - Nature, 1980 - nature.com
Slow-reacting substance of anaphylaxis (SRS-A) is a primary mediator of immediate-type
hypersensitivity reactions, probably having a major bronchoconstrictor role in asthma. …

Leukotriene release by endometrium and myometrium throughout the menstrual cycle in dysmenorrhoea and menorrhagia

MCP Rees, V Di Marzo, JR Tippins… - Journal of …, 1987 - joe.bioscientifica.com
Endometrium and myometrium were collected at hysterectomy from 21 women with measured
menstrual blood loss. Eight women complained of dysmenorrhoea and the remaining 13 …

CGRP: a novel neuropeptide from the calcitonin gene is the most potent vasodilator known.

JR Tippins - Journal of hypertension. Supplement: Official Journal of …, 1986 - europepmc.org
The calcitonin gene has been shown to give rise to another peptide, calcitonin gene-related
peptide (CGRP). The structure of human CGRP has been determined by mass spectrometry. …

Coronary artery constriction by the isoprostane 8-epi prostaglandin F2 alpha.

BM Kromer, JR Tippins - British journal of pharmacology, 1996 - ncbi.nlm.nih.gov
This study was undertaken to compare the effects of 8-epi prostaglandin F2 alpha (8-epi
PGF2 alpha) to those of prostaglandin F2 alpha (PGF2 alpha) and U46619, a thromboxane …

The myotropic and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP)

JR Tippins, HR Morris, M Panico, T Etienne, P Bevis… - Neuropeptides, 1984 - Elsevier
Human and rat calcitonin gene-related peptides cause a dose-related contraction of guinea
pig ileum, which is antagonised by an anti-histamine, mepyramine, and an anticholinergic …