Systemic antifungal agents: drug interactions of clinical significance

E Albengres, H Le Louët, JP Tillement - Drug safety, 1998 - Springer
There are 3 main classes of systemic antifungals: the polyene macrolides (eg amphotericin
B), the azoles (eg the imidazoles ketoconazole and miconazole and the triazoles …

Drug binding in plasma: a summary of recent trends in the study of drug and hormone binding

…, S Urien, E Albengres, JC Duché, JP Tillement - Clinical …, 1994 - Springer
Tillement JP The relationshIp between plasma protein bmding distnbutlOn and
phannacokmetic of drugs. In TIilement JP (Ed.) Advances in pharmacology and therapeutics, Vol. …

Mitochondria as target for antiischemic drugs

D Morin, T Hauet, M Spedding, JP Tillement - Advanced drug delivery …, 2001 - Elsevier
The cessation of blood flow followed by a reperfusion period results in severe damages to
cell structures. This induces a complex cascade of events involving, more particularly, a loss …

Drug transfer across the blood‐brain barrier: correlation between in vitro and in vivo models

…, JC Fruchart, R Cecchelli, JP Tillement - Journal of …, 1992 - Wiley Online Library
To assess the drug transport across the blood‐brain barrier (BBB), we compared the
maximal brain extraction values at time 0 [E(0) values] obtained using either in vitro or in vivo …

Effects of resveratrol on the rat brain respiratory chain.

…, A Bertelli, AA Bertelli, JP Tillement - … under experimental and …, 1999 - europepmc.org
The aim of this work was to investigate the possible effects of resveratrol on the mitochondrial
respiratory chain in rat brains. Isolation of mitochondria was performed at 4 degrees C …

Structure–property relationships of trimetazidine derivatives and model compounds as potential antioxidants

…, B Testa, F Brée, R Zini, JP Tillement… - Free Radical Biology …, 1998 - Elsevier
Twenty-five compounds (trimetazidine derivatives and other compounds, mostly having a
free phenolic group) were examined for their radical scavenging and antioxidant properties. …

Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood

M Lemaire, JP Tillement - Journal of Pharmacy and …, 1982 - Wiley Online Library
The distribution of cyclosporin A between plasma, leucocytes and erythrocytes was studied
in vitro by means of sedimentation in Ficoll‐Paque and dextran. The uptake by erythrocytes …

Equilibrium dialysis, ultrafiltration, and ultracentrifugation compared for determining the plasma-protein-binding characteristics of valproic acid.

…, JM Chamouard, G Houin, JP Tillement - Clinical …, 1985 - academic.oup.com
Equilibrium dialysis, ultrafiltration, and ultracentrifugation were compared to determine their
reliability and applicability in the study of binding of an anticonvulsant drug, valproic acid, by …

Plasma, urine and tissue levels of trans-and cis-resveratrol (3, 4', 5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats.

…, R Stradi, A Bertelli, JP Tillement - … journal of tissue …, 1996 - europepmc.org
The aim of the present study was to evaluate the absorption, the concentration in different
organs and the excretion of natural trans-and cis-resveratrol after red wine oral administration …

[HTML][HTML] Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation

…, S Barthélémy, R Zini, S Labidalle, JP Tillement - FEBS letters, 2001 - Elsevier
Curcumin is a natural compound showing antiproliferative properties. Recent studies
suggest that these properties might be due to its ability to induce apoptosis in tumor cells. As …