… J., Reductive metabolism of halothane by human and rabbit cytochrome P-450. Binding of 1
-… growth hormone secretion and hepatic cytochrome P450 isozymes of the rat, J. Phurmucol. …

Acetaminophen (APAP), a widely used over-the-counter analgesic, is known to cause
hepatotoxicity when ingested in large quantities in both animals and man, especially when …

The peroxisome proliferator activated receptor α (PPAR) is a member of the steroid/hormone
receptor superfamily that mediates the peroxisome proliferator-dependent transcriptional …

The human P450111 family has been shown to be composed of at least four members,
P450I1IA3 (HLp), P450II1A4(P45ONF), P45OlIlA5(HLp3), and P450I1IA6(HLp2). Due to the lack …

Revised Manuscript Received December 27, 1990 abstract: The present study characterizes
the profile of cDNAs from the human P450IIC subfamily in a library from one individual, and …

… , hepatocytes from three separate subjects (HH988, HH993, and HH984) exhibited CYP3A4
concentrations at 48 h that were 94 ± 6% of the content found in zero time cells (JL Raucy …

… Microsomes of human livers were prepared as described by Raucy and Lasker (1991).
SDS-polyacrylamide gelelectrophoresis and immunoblot analysis were performed as above …

Induction of cytochrome P450 3A (CYP3A) by xenobiotics may lead to clinically relevant
drug interactions. In contrast with other CYP3A family members, studies on the inducibility of …

In the present study, the regio- and stereoselective epoxidation of arachidonic acid by
cytochromes P450 2C8 and 2C9, two members of the CYP2C gene subfamily expressed in …

Hepatic microsomal metabolism of delta 1-tetrahydrocannabinol (THC) has been
extensively studied in many rodent species, but there have been few reports describing such …