Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: results of a pilot study
PD Trautman, HFL Meyer-Bahlburg, J Postelnek… - …, 1995 - Elsevier
The effect of early prenatal dexamethasone (DEX) exposure on cognitive and behavioral
development, behavior problems, and temperament were examined in 26 consecutively …
development, behavior problems, and temperament were examined in 26 consecutively …
RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents
D Xu, Y Kim, J Postelnek, MD Vu, DQ Hu, C Liao… - … of Pharmacology and …, 2012 - ASPET
Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have
been shown to prevent the development of collagen-induced arthritis (CIA) in mice, …
been shown to prevent the development of collagen-induced arthritis (CIA) in mice, …
Selective Itk inhibitors block T-cell activation and murine lung inflammation
…, R Townsend, J Postelnek, SH Spergel, J Lin… - Biochemistry, 2004 - ACS Publications
Nonreceptor protein tyrosine kinases including Lck, ZAP-70, and Itk play essential roles in T-cell
receptor (TCR) signaling. Gene knockout studies have revealed that mice lacking these …
receptor (TCR) signaling. Gene knockout studies have revealed that mice lacking these …
Suppression of glomerulonephritis in lupus‐prone NZB× NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase
…, M Giron, KY Lau, J Hang, J Postelnek… - Arthritis & …, 2013 - Wiley Online Library
Objective Bruton's tyrosine kinase (BTK) plays a critical role in B cell development and function.
We recently described a selective BTK inhibitor, RN486, that blocks B cell receptor (BCR…
We recently described a selective BTK inhibitor, RN486, that blocks B cell receptor (BCR…
Abstract CT180: Preliminary phase 1 profile of BMS-986179, an anti-CD73 antibody, in combination with nivolumab in patients with advanced solid tumors
…, E Hilt, M Donovan, A Gipson, P Basciano, J Postelnek… - Cancer Research, 2018 - AACR
Background: CD73 is an ectonucleotidase that converts adenosine monophosphate to
adenosine, a potent immunosuppressive soluble mediator that inhibits the cytotoxic function of …
adenosine, a potent immunosuppressive soluble mediator that inhibits the cytotoxic function of …
Prophylactic administration of abatacept prevents disease and bone destruction in a rat model of collagen-induced arthritis
C Kliwinski, D Kukral, J Postelnek, B Krishnan… - Journal of …, 2005 - Elsevier
Abatacept is the first in a new class of agents that selectively modulates T-cell activation by
attenuating CD28-mediated co-stimulation. This study examined the effects of abatacept on …
attenuating CD28-mediated co-stimulation. This study examined the effects of abatacept on …
A highly selective inhibitor of IκB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft …
RM Townsend, J Postelnek, V Susulic… - …, 2004 - journals.lww.com
Background. We previously demonstrated in vitro and in vivo that an IκB kinase (IKK) inhibitor
blocks cytokine production and suppresses immune responses. These results indicate that …
blocks cytokine production and suppresses immune responses. These results indicate that …
Novel Pyrrolidine Ureas as C− C Chemokine Receptor 1 (CCR1) Antagonists
…, R Liu, R Zhang, B Jacob, J Postelnek… - Journal of medicinal …, 2009 - ACS Publications
Monocyte infiltration is implicated in a variety of diseases including multiple myeloma,
rheumatoid arthritis, and multiple sclerosis. C−C chemokine receptor 1 (CCR1) is a chemokine …
rheumatoid arthritis, and multiple sclerosis. C−C chemokine receptor 1 (CCR1) is a chemokine …
Mothers' reactions to prenatal diagnostic procedures and dexamethasone treatment of congenital adrenal hyperplasia
…, HFL Meyer-Bahlburg, J Postelnek… - Journal of …, 1996 - Taylor & Francis
A retrospective survey of mothers' attitudes toward and experiences of chorionic villus sampling,
amniocentesis and dexamethasone (DEX) treatment was conducted in 38 women who …
amniocentesis and dexamethasone (DEX) treatment was conducted in 38 women who …
[HTML][HTML] 606 Biomarker analyses of baseline tumor specimens and on-treatment changes in sera samples of patients enrolled in the RELATIVITY-047 trial to …
…, E Lipson, D Schadendorf, J Wojcik, J Postelnek… - 2022 - jitc.bmj.com
Background The phase 2/3 RELATIVITY-047 clinical trial (NCT03470922) in patients with
previously untreated metastatic or unresectable melanoma met its primary endpoint of …
previously untreated metastatic or unresectable melanoma met its primary endpoint of …